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Hoeffer, Charles Albert Assistant Professor

Positions

Research Areas research areas

Research

research overview

  • My research deals with identifying the molecular mechanisms involved in the manifestation of synaptic plasticity and memory in human neurological diseases. I have focused on identifying specific molecular lesions in neuronal signaling pathways and how these play a role in the manifestation of cellular and behavioral deficits in disorders and diseases such as Down syndrome (DS) and Alzheimer’s disease (AD). I use mouse disease and mutant models in combination with behavioral, genetic, and pharmacological approaches to address modeled behavioral deficits and then translate this work to therapies aimed at alleviating human symptoms of neurological disorders and psychiatric disease.

keywords

  • Behavior, Psychiatric disease, Animal model, Hippocampus, Molecular signaling, Molecular biology, Neurodegeneration, Alzheimer's disease, Down Syndrome, Schizophrenia, electrophysiology, protein synthesis, Genetics, Transgenic mouse, Anxiety, Calcineurin, Cellular physiology, Translation, GABAergic, Memory, Learning, Synaptic plasticity, Tauopathy

Publications

selected publications

Teaching

courses taught

  • IPHY 2910 - Practicum in Integrative Physiology
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Fall 2019
    Offers practical experience in organized situations with direct supervision. May be repeated up to 6 total credit hours.
  • IPHY 3010 - Teaching in Integrative Physiology
    Primary Instructor - Fall 2018 / Fall 2019
    Provides an opportunity to assist in teaching specific laboratory sections in IPHY under direct faculty supervision. Students must make arrangements with the faculty member responsible for the course in which they plan to assist. May be repeated up to 6 total credit hours.
  • IPHY 4010 - Seminar in Integrative Physiology
    Primary Instructor - Fall 2019
    Introduces a small group of students to current research topics in integrative physiology, evaluation of current research and discussion of critical issues. May be repeated up to 6 total credit hours when topics vary. Department enforced prerequisite: IPHY 2800 or equivalent.
  • IPHY 4600 - Immunology
    Primary Instructor - Fall 2018 / Fall 2019
    Studies the immune system, a multi-cellular system that functions to protect us from disease. Introduces concepts associated with the development and function of individual cells of the immune system (T-cells, B-cells, neutrophils, dendritic cells, macrophages), as well as their integrative roles in physiology and host defense. Department enforced prerequisites: one year of general biology (lecture + lab) and one year of general chemistry (lecture + lab). Recommended prerequisite: IPHY 3060. Same as IPHY 5600.
  • IPHY 4870 - Honors Thesis
    Primary Instructor - Spring 2018 / Spring 2019
    Department enforced prerequisites: IPHY 2800 and IPHY 3700.
  • IPHY 4930 - Internship
    Primary Instructor - Spring 2018 / Summer 2018 / Spring 2019 / Summer 2019
    Provides an opportunity for field/laboratory work in a variety of different settings. Consult with faculty for approval. May be repeated up to 6 total credit hours. Department enforced prerequisite: completion of at least two of the major core classes.
  • IPHY 6010 - Seminar
    Primary Instructor - Spring 2019
    Presents special topics in integrative physiology. May be repeated up to 6 total credit hours.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Fall 2019
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.

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