- The main focus of my laboratory will be comparative medicine research. There are many unanswered questions regarding best practices in animal care and management. Oftentimes regulations are imposed arbitrarily with little support or validation from scientific standpoint. Performance base standards are promulgated by the Guide for Care of Use of Laboratory Animals and these factors must be evaluated using the scientific method and objective data. This allows for controlled evaluation for animal models and a direct assessment of regulated standards vs performance based on the reliability and reproducibility of data. Contemporary issues impacting best practices include appropriate husbandry and sanitation, variables impacting animal welfare and behaviors such as disinfectant, noise, vibration, diet, water, and operational methods and infrastructural designs that influence research data validity and reproducibility.