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Borden, Mark A

Professor

Positions

Research Areas research areas

Research

research overview

  • My research group investigates colloids and membranes with a focus on biomedical applications. Our strength is design and engineering of novel microbubble formulations for medical imaging, drug delivery, gene therapy and blood gas delivery. Microbubbles are stabilized spherical gas particles that are smaller than a red blood cell. For example, we are researching (1) targeted microbubbles for ultrasound molecular imaging, with a focus on evaluating tumor perfusion and angiogenesis and reducing the immunogenicity, (2) surface engineered microbubbles for multi-modality imaging, (3) multi-functional microbubbles for image-guided drug delivery, and (4) microbubble foams for intravenous oxygen delivery. We also specialize in colloidal and interfacial science aspects of microbubbles and other emulsions. For example, we are researching (1) the mechanical properties of the thin lipid film that coats microbubbles, emulsions and lung alveoli, and (2) factors that affect emulsion stability.

keywords

  • contrast agents, theranostics, colloids, biocolloids, emulsions, foams, microbubbles, image-guided drug delivery, targeted gene therapy, intravenous oxygen delivery

Publications

selected publications

Teaching

courses taught

  • BMEN 1000 - Exploring Biomedical Engineering
    Primary Instructor - Spring 2021 / Spring 2022 / Spring 2023
    Introduces the biomedical engineering profession, curriculum, career pathways, ethics and responsibilities, and research opportunities. Academic and industry speakers are invited to address various biomedical engineering topics. Recommended Restriction: Students in second semester of Biomedical Engineering curriculum or higher.
  • BMEN 2000 - Introduction to Biomedical Engineering
    Primary Instructor - Spring 2019 / Spring 2020 / Spring 2021 / Fall 2021
    Introduces important aspects of human physiology and develops a basic understanding of the biomedical engineering field. Topics include biomechanics, bioinstrumentation, bioimaging, biotechnology and biomaterials. Recommended prerequisite: high school biology.
  • BMEN 3010 - Biotransport
    Primary Instructor - Fall 2021 / Fall 2022
    An introduction to the modeling of complex biological systems using principles of transport phenomena and biochemical kinetics. Includes the conservation of mass and momentum; rheology of Newtonian and non-Newtonian fluids; steady and transient diffusion in reacting systems; dimensional analysis; homogeneous versus heterogeneous reaction systems; and physiological transport systems, including oxygen and drug transport. Recommended restriction: for students in fifth semester of Biomedical Engineering curriculum or higher.
  • BMEN 6950 - Master's Thesis
    Primary Instructor - Spring 2021 / Summer 2021 / Spring 2023
    Work with a faculty advisor on a masters thesis.
  • MCEN 3022 - Heat Transfer
    Primary Instructor - Fall 2018
    Studies fundamentals of heat transfer by conduction, convection, and radiation. Emphasizes problem formulation and selection of appropriate solution techniques. Provides applications to modern engineering systems, which may include energy, biological, environmental, and materials engineering problems.
  • MCEN 4228 - Special Topics in Mechanical Engineering
    Secondary Instructor - Fall 2019
    Subject matter to be selected from topics of current interest. May be repeated up to 15 credit hours. Same as MCEN 5228.
  • MCEN 5228 - Special Topics in Mechanical Engineering
    Secondary Instructor - Fall 2019
    Subject matter to be selected from topics of current interest. May be repeated up to 15 credit hours.
  • MCEN 6228 - Special Topics
    Primary Instructor - Spring 2018
    Subject matter to be selected from topics of current interest. May be repeated up to 15 total credit hours.
  • NCEN 2030 - Biomedical Engineering Research Program
    Primary Instructor - Spring 2021
    Biomedical Engineering Research Program

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