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Publications in VIVO
 

Rinn, John The Leslie Orgel Professor in RNA Science and Marvin H Caruthers Endowed Chair

Positions

Research Areas research areas

Research

research overview

  • It has become increasingly clear that the mammalian genome encoded numerous long noncoding RNA (lncRNA) genes. Our research program continues to push the forefront in understanding long noncoding RNAs (lncRNAs) from identifying and mapping thousands of lncRNA loci -- to developing numerous mutant lncRNA mouse models demonstrating the important impact of lncRNA loci in development and disease -- to dissecting the molecular modalities and mechanisms of lncRNAs in transcriptional and epigenetic regulation. Central to our approach is to bridge the computational and experimental sciences to identify functional long noncoding RNAs. This combinatorial and multi-faceted approach is critical to advance our understanding of how lncRNAs influence cell fate, transcriptional regulation and nuclear architecture. Underscoring the importance of this approach many of the lncRNAs we study are found to be implicated in human disease.

keywords

  • lncRNA, lincRNA, noncoding RNA, ncRNA, epigenetics, noncoding DNA, nuclear organization, RNA, DNA, Genome, Chromatin, epigenetic, splicing

Publications

selected publications

Teaching

courses taught

  • CHEM 5780 - Fundamentals of Biochemistry II
    Primary Instructor - Spring 2018 / Spring 2019
    Analysis of topics in biochemistry including protein structure, methods of structure determination and prediction, protein folding, and protein dynamics. Intended as a comprehensive treatment of areas central to modern biochemistry for entering graduate students. Lectures concurrent with CHEM 5781, covering the same topics except for the requirement of a written research proposal. Formerly CHEM 5780.
  • CHEM 5781 - Advanced General Biochemistry 2
    Primary Instructor - Spring 2018 / Spring 2019
    Lect. Detailed consideration of contemporary topics in biochemistry, including protein structure (primary, secondary, tertiary, and quaternary), methods of structure determination and prediction, protein folding (kinetics, thermodynamics, denaturation, and renaturation), and protein dynamics (internal motions and methods of analysis). Formerly CHEM 5781.
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Fall 2018 / Spring 2019
    May be repeated up to 15 total credit hours.

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles