The development of fluorescence imaging techniques has revolutionized our ability to visualize cellular processes in real time. We now has the ability to interrogate specific proteins, molecules, and ions in cells with unprecedented spatial and temporal resolution. The focus of our lab is to expand this 'toolkit' to develop probes for imaging cellular metal homeostasis and bacterial pathogenesis. These targets represent fascinating examples of the complexity of cellular signaling networks and they have been implicated in diseases such as Alzheimer's disease and cancer, as well as processes such as neurodegeneration and persistent bacterial infections. In our laboratory the creation of novel imaging probes to shed light on cell biology are inextricably linked. Our research combines biophysical techniques, protein design and engineering for the development of novel probes, and cellular imaging studies to elucidate the mechanisms of cellular signaling pathways.
live cell imaging, development of fluorescent sensors, development of imaging technology, imaging of cellular signaling
CHEM 1400 - Foundations of Chemistry
Covers core concepts in chemistry: nature of matter (atomic and molecular structure, bonding and macroscopic properties), transformations of matter (chemical reactivity), and quantifying chemical transformations (thermochemistry, thermodynamics and kinetics). Emphasizes critical thinking and cultivate core problem solving skills utilized by scientists. Intended for first semester CHEM/BCHM majors. Department enforced prerequisites: one year high school chemistry or CHEM 1021 (minimum grad C-) and high school math through pre-calculus. Not recommended for students with grades below B- in CHEM 1021. Department enforced corequisite: CHEM 1401. Credit not granted for this course and CHEM 1113. Formerly CHEM 1251.
CHEM 6901 - Research in Chemistry
Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
May be repeated up to 15 total credit hours.
MCDB 6000 - Introduction to Laboratory Methods
Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.