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Johnson, Thomas E Professor

Positions

Research Areas research areas

Research

research overview

  • I have characterized longevity genes in C. elegans to see how these mutations induce increased resistance to oxidative stress. I developed a molecular understanding of the mechanisms of hormesis in response to heat stress. I study stochastics of response to heat as a biomarker that predicts subsequent longevity. I utilize such techniques as high-throughput RNAi screening, CRISPR ,microarray, and bioinformatics. I am interested in aging in mice, studying it through newly induced mutants that lengthen mouse life and health. We have developed a novel and patented resource wherein we select for resistance to a stressor (e.g. paraquat) using embryonic stem cells which can then be turned into mice which carry the stress resistance trait. We have begun to apply these methods to the identification of cryogenic targets that may allow extended preservation of human organs. Finally, we have patented both molecular targets and FDA approved drugs that could turn out to be worth billions.

keywords

  • Aging, Caenorhabditis elegans, Nematodes, Mus musculus, Genetics, Physiology, Genomics, Stress, Microarrays, Behavior, Longevity, Health, Hormesis, Fetal Alcohol Syndrome, Dietary Restriction, Healthspan, Biomarkers, Genetic Regulation, QTL, Stochastic Effects on Gene Expression, Heat Shock Proteins, Free Radicals, Oxidative Stress, DAF-16/FOXO, Regulation, Reproduction, Male Fertility, Rejuvenation, Reporters of Gene Expression, Invertebrates, Cryobiology, Organ Preservation, Resilience

Publications

selected publications

Teaching

courses taught

  • IPHY 2910 - Practicum in Integrative Physiology
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Fall 2019 / Spring 2020
    Offers practical experience in organized situations with direct supervision. May be repeated up to 6 total credit hours.
  • IPHY 4870 - Honors Thesis
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Department enforced prerequisites: IPHY 2800 and IPHY 3700.
  • IPHY 4930 - Internship
    Primary Instructor - Spring 2018 / Summer 2018 / Spring 2019 / Summer 2019
    Provides an opportunity for field/laboratory work in a variety of different settings. Consult with faculty for approval. May be repeated up to 6 total credit hours. Department enforced prerequisite: completion of at least two of the major core classes.
  • IPHY 5102 - Introduction to Physiology Genomics
    Primary Instructor - Fall 2018
    Covers recent developments in genomics: a body of revolutionary new approaches that deal with the analysis of all the DNA sequence in the cell. Relies on a genomics text and student presentation/discussion aided by a study guide. Recommended prerequisite: IPHY 5200.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Fall 2019 / Spring 2020
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles