I have characterized longevity genes in C. elegans to see how these mutations induce increased resistance to oxidative stress. I developed a molecular understanding of the mechanisms of hormesis in response to heat stress. I study stochastics of response to heat as a biomarker that predicts subsequent longevity. I utilize such techniques as high-throughput RNAi screening, CRISPR ,microarray, and bioinformatics. I am interested in aging in mice, studying it through newly induced mutants that lengthen mouse life and health. We have developed a novel and patented resource wherein we select for resistance to a stressor (e.g. paraquat) using embryonic stem cells which can then be turned into mice which carry the stress resistance trait. We have begun to apply these methods to the identification of cryogenic targets that may allow extended preservation of human organs. Finally, we have patented both molecular targets and FDA approved drugs that could turn out to be worth billions.
Aging, Caenorhabditis elegans, Nematodes, Mus musculus, Genetics, Physiology, Genomics, Stress, Microarrays, Behavior, Longevity, Health, Hormesis, Fetal Alcohol Syndrome, Dietary Restriction, Healthspan, Biomarkers of Aging, Genetic Regulation, QTL, Stochastic Effects on Gene Expression, Heat Shock Proteins, Free Radicals, Oxidative Stress, DAF-16/FOXO, Regulation of Aging, Reproduction, Male Fertility, Rejuvenation, Reporters of Gene Expression, Invertebrates, Cryobiology, Organ Preservation