• Contact Info
Publications in VIVO
 

Johnson, Thomas E Professor

Positions

Research Areas research areas

Research

research overview

  • I have characterized longevity genes in C. elegans to see how these mutations induce increased resistance to oxidative stress. I developed a molecular understanding of the mechanisms of hormesis in response to heat stress. I study stochastics of response to heat as a biomarker that predicts subsequent longevity. I utilize such techniques as high-throughput RNAi screening, CRISPR ,microarray, and bioinformatics. I am interested in aging in mice, studying it through newly induced mutants that lengthen mouse life and health. We have developed a novel and patented resource wherein we select for resistance to a stressor (e.g. paraquat) using embryonic stem cells which can then be turned into mice which carry the stress resistance trait. We have begun to apply these methods to the identification of cryogenic targets that may allow extended preservation of human organs. Finally, we have patented both molecular targets and FDA approved drugs that could turn out to be worth billions.

keywords

  • Aging, Caenorhabditis elegans, Nematodes, Mus musculus, Genetics, Physiology, Genomics, Stress, Microarrays, Behavior, Longevity, Health, Hormesis, Fetal Alcohol Syndrome, Dietary Restriction, Healthspan, Biomarkers, Genetic Regulation, QTL, Stochastic Effects on Gene Expression, Heat Shock Proteins, Free Radicals, Oxidative Stress, DAF-16/FOXO, Regulation, Reproduction, Male Fertility, Rejuvenation, Reporters of Gene Expression, Invertebrates, Cryobiology, Organ Preservation, Resilience

Publications

selected publications

Teaching

courses taught

  • IPHY 4860 Independent Study: Undergraduate (Spring 2019)
  • IPHY 4870 Honors Thesis (Spring 2019)
  • IPHY 4930 Internship (Spring 2019)
  • IPHY 5840 Graduate Independent Study (Spring 2019)
  • IPHY 6840 Research Project (Spring 2019)
  • IPHY 6950 Master's Thesis (Spring 2019)
  • IPHY 8990 Doctoral Dissertation (Spring 2019)
  • IPHY 5840 Graduate Independent Study (Fall 2018)
  • IPHY 6840 Research Project (Fall 2018)
  • IPHY 6950 Master's Thesis (Fall 2018)
  • IPHY 8990 Doctoral Dissertation (Fall 2018)
  • IPHY 2910 Practicum in Integrative Physiology (Summer 2018)
  • IPHY 4860 Independent Study: Undergraduate (Summer 2018)
  • IPHY 4930 Internship (Summer 2018)
  • IPHY 5840 Graduate Independent Study (Summer 2018)
  • IPHY 6840 Research Project (Summer 2018)
  • IPHY 6950 Master's Thesis (Summer 2018)
  • IPHY 8990 Doctoral Dissertation (Summer 2018)
  • IPHY 2910 Practicum in Integrative Physiology (Spring 2018)
  • IPHY 4860 Independent Study: Undergraduate (Spring 2018)
  • IPHY 4870 Honors Thesis (Spring 2018)
  • IPHY 4930 Internship (Spring 2018)
  • IPHY 5840 Graduate Independent Study (Spring 2018)
  • IPHY 6840 Research Project (Spring 2018)
  • IPHY 6950 Master's Thesis (Spring 2018)
  • IPHY 8990 Doctoral Dissertation (Spring 2018)

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles