Publications in VIVO

Co-author Network

DeSouza, Christopher A Professor

Positions

Professor, Integrative Physiology

Research Areas

Research

research overview

My research is focused on the effects of cardiovascular and metabolic risk factors, HIV-1 infection on vascular endothelial cell function and repair. In addition, my laboratory studies the effects of lifestyle and pharmacological interventions on vascular endothelial cell biology.

Publications

selected publications

conference proceeding
- Diminished Endothelial Fibrinolytic Function With Prehypertension. Hypertension. 2013
- Exercise and hypertension in older adults. 45-50. 1998
journal article
- High glucose derived endothelial microparticles increase active caspase-3 and reduce microRNA-Let-7a expression in endothelial cells. Biochemical and Biophysical Research Communications. 1026-1029. 2017
- Regular aerobic exercise reduces endothelin-1-mediated vasoconstrictor tone in overweight and obese adults. Experimental Physiology. 1133-1142. 2017
- Influence of sex on the number of circulating endothelial microparticles and microRNA expression in middle-aged adults. Experimental Physiology. 894-900. 2017
- Passive heat stress reduces circulating endothelial and platelet microparticles. Experimental Physiology. 663-669. 2017
- ENDOTHELIN-1 SYTEM ACTIVITY IN ADULTS WITH BORDERLINE HIGH LDL-CHOLESTEROL.. Artery Research. 115-118. 2014
- Influence of Dietary Saturated Fat Intake on Endothelial Fibrinolytic Capacity in Adults. American Journal of Cardiology. 783-788. 2014
- Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in overweight/obese adults. Metabolism. 951-956. 2014
- Influence of Elevated Levels of C-Reactive Protein on Circulating Endothelial Progenitor Cell Function. Clinical and Translational Science. 137-140. 2014
- Impaired fasting blood glucose is associated with increased endothelin-1 vasoconstrictor tone. Atherosclerosis. 130-133. 2013
- Metabolic Syndrome and Endothelin-1 mediated vasoconstrictor tone in overweight/obese adults. Federation proceedings. 2013
- Short Sleep Duration and Endothelial t-PA Release in Overweight/Obese Adults. Federation proceedings. 2013
- Self-Reported Habitual Short Sleep Duration Is Associated with Endothelial Fibrinolytic Dysfunction in Men: A Preliminary Report. SLEEP. 183-188. 2013
- Effects of endothelin-1 on endothelial progenitor cell function. Clinical Chemistry and Laboratory Medicine. 1121-1124. 2012
- White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults.. Artery Research. 65-70. 2012
- Elevated Endothelin-1 Vasoconstrictor Tone in Prehypertensive Adults. Canadian Journal of Cardiology. 347-353. 2012
- Nitric Oxide-Mediated Endothlium-Dependent Vasodilation Is Impaired with Borderline High-LDL Cholesterol. Clinical and Translational Science. 21-26. 2012
- Relation of C-Reactive Protein to Endothelial Fibrinolytic Function in Healthy Adults. American Journal of Cardiology. 1675-1679. 2011
- CD31(+) T Cells, Endothelial Function and Cardiovascular Risk. Heart, Lung and Circulation. 659-662. 2011
- Enhanced endothelin-1 system activity with overweight and obesity. AJP - Heart and Circulatory Physiology. H689-H695. 2011
- Influence of Abdominal Obesity on Vascular Endothelial Function in Overweight/Obese Adult Men. Obesity Research. 1742-1746. 2011
- Prehypertension Is Associated With Impaired Nitric Oxide-Mediated Endothelium-Dependent Vasodilation in Sedentary Adults. American Journal of Hypertension. 976-981. 2011
- Endothelin-I vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men. Clinical Science. 485-491. 2011
- C-Reactive Protein-Related Endothelial Vasodilator Dysfunction in Healthy Adults. Federation proceedings. 2011
- Effects of HIV-1 gp120 and Protease Inhibitors on Apoptotic Susceptibility of CD34+Hematopoietic Progenitor Cells. Federation proceedings. 2011
- Habitual short sleep duration and circulating endothelial progenitor cells.. Journal of Cardiovascular Disease Research. 110-114. 2011
- Impaired Nitric Oxide Mediated Endothelium-Dependent Vasodilation with Suboptimal LDL Cholesterol. Federation proceedings. 2011
- Effects of HIV-1 gp120 and Protease Inhibitors on Apoptotic Susceptibility of CD34(+) Hematopoietic Progenitor Cells. Journal of Acquired Immune Deficiency Syndromes. E49-E50. 2011
- Aging Is Associated with a Proapoptotic Endothelial Progenitor Cell Phenotype. Journal of Vascular Research. 408-414. 2011
- Prehypertension and endothelial progenitor cell function. Journal of Human Hypertension. 57-62. 2011
- Human aging and CD31(+) T-cell number, migration, apoptotic susceptibility, and telomere length. Journal of applied physiology: respiratory, environmental and exercise physiology. 1756-1761. 2010
- Endothelial Progenitor Cell Function, Apoptosis, and Telomere Length in Overweight/Obese Humans. Obesity Research. 1677-1682. 2010
- Osteopenia and endothelin-1-mediated vasconstrictor tone in postmenopausal women. BONE. 542-545. 2010
- Regular Aerobic Exercise, Without Weight Loss, Improves Endothelium-dependent Vasodilation in Overweight and Obese Adults. Obesity Research. 1667-1669. 2010
- Short sleep duration is associated with enhanced endothelin-1 vasoconstrictor tone. Canadian Journal of Physiology and Pharmacology. 777-781. 2010
- Epigenetics: an emerging player in health and disease. Journal of applied physiology: respiratory, environmental and exercise physiology. 230-231. 2010
- Influence of Aging on Angiogenic T cells. Federation proceedings. 2010
- Short Sleep Duration and Endothelial Progenitor Cell Function. Federation proceedings. 2010
- CD31(+) T cells represent a functionally distinct vascular T cell phenotype. Blood Cells, Molecules and Diseases. 74-78. 2010
- Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adults. AJP - Regulatory, Integrative and Comparative Physiology. R261-R265. 2010
- CD31+T Cells Represent a Functionally Distinct Vascular T Cell Phenotype. Federation proceedings. 2009
- Effects of endothelin-1 on endothelial progenitor cell function. Federation proceedings. 2009
- Endothelial Tissue-Type Plasminogen Activator Release Is Reduced in Older Adults with Metabolic Syndrome. Circulation. E291-E292. 2009
- Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults. International Journal of Obesity. 219-225. 2009
- Aging and endothelial progenitor cell telomere length in healthy men. Clinical Chemistry and Laboratory Medicine. 47-50. 2009
- Gender and Endothelial Progenitor Cell Number in Middle-Aged Adults.. Artery Research. 156-160. 2008
- Habitual exercise and arterial aging. Journal of applied physiology: respiratory, environmental and exercise physiology. 1323-1332. 2008
- Acute and chronic effects of vitamin C on endothelial fibrinolytic function in overweight and obese adult humans. Journal of Physiology. 3525-3535. 2008
- Endothelin-1, aging and hypertension. Current Opinion in Cardiology. 350-355. 2008
- Aging is associated with a proapoptotic endothelial progenitor cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. E140-E140. 2008
- Influence of adiposity on endothelial progenitor cell number and clonogenic capacity. Arteriosclerosis, Thrombosis, and Vascular Biology. E145-E145. 2008
- Prehypertension and endothelial progenitor cell function. Arteriosclerosis, Thrombosis, and Vascular Biology. E146-E146. 2008
- Shortened telomere length in endothelial progenitor cells with age. Arteriosclerosis, Thrombosis, and Vascular Biology. E105-E105. 2008
- Aging and EPC Release of Proangiogenic Factors. Federation proceedings. 2008
- Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists. AJP - Heart and Circulatory Physiology. H1685-H1692. 2008
- Metabolic syndrome and endothelial fibrinolytic capacity in obese adults. AJP - Regulatory, Integrative and Comparative Physiology. R39-R44. 2008
- Feasibility of molecular analysis of percutaneously collected peripheral atheroma. American Journal of Cardiology. 83L-83L. 2007
- Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension. 403-409. 2007
- Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men. Journal of applied physiology: respiratory, environmental and exercise physiology. 847-852. 2007
- Aging, exercise, and endothelial progenitor cell apoptosis. Circulation. E251-E251. 2007
- Endothelin-1 vasoconstrictor activity contributes to impaired acetylcholine-mediated vasodilation in obesity. Circulation. E242-E242. 2007
- Gender differences in circulating endothelial progenitor cell colony-forming capacity and migratory activity in middle-aged adults. American Journal of Cardiology. 46-48. 2007
- Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity Research. 2127-2131. 2006
- Greater oxidative stress and inflammatory burden in obese adults with the metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology. E84-E85. 2006
- Regular aerobic exercise alleviates the age-related increase in endothelin-1 mediated vasoconstrictor tone. Arteriosclerosis, Thrombosis, and Vascular Biology. E99-E99. 2006
- Sex differences in circulating endothelial progenitor cell colony forming capacity and migratory activity in middle-aged adult humans. Arteriosclerosis, Thrombosis, and Vascular Biology. E89-E89. 2006
- Vitamin C supplementation improves endothelial t-PA release in obese adults. Arteriosclerosis, Thrombosis, and Vascular Biology. E103-E103. 2006
- Impaired endothelium-dependent vasodilation in normotensive and normoglycemic obese adult humans. Journal of Cardiovascular Pharmacology. 310-313. 2006
- Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise. AJP - Endocrinology and Metabolism. E807-E813. 2005
- Letter regarding article by Christou et al, "Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men" - Response. Circulation. E253-E254. 2005
- Endothelial nitric oxide synthase inhibition does not alter endothelial progenitor cell colony forming capacity or migratory activity. Journal of Cardiovascular Pharmacology. 387-389. 2005
- Basal endothelial nitric oxide release is preserved in overweight and obese adults. Obesity Research. 1303-1306. 2005
- Estrogen receptor-alpha thymidine and adenine repeat polymorphism and endothelial fibrinolytic regulation in postmenopausal women. American Journal of Obstetrics and Gynecology. 366-370. 2005
- Gender differences in endothelial tissue-type plasminogen activator release in middle-aged adults. Journal of the American College of Cardiology. 1547-1549. 2005
- Beneficial effects of exercise on age-related reductions in endothelial progenitor cell number and migratory activity. Arteriosclerosis, Thrombosis, and Vascular Biology. E50-E50. 2005
- Endothelial nitric oxide synthase inhibition does not alter endothelial progenitor cell colony forming capacity or migratory activity. Arteriosclerosis, Thrombosis, and Vascular Biology. E85-E85. 2005
- Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation. 1904-1914. 2005
- Estrogen receptor-alpha polymorphism and endothelial fibrinolytic regulation in postmenopausal women. Circulation. E51-E51. 2005
- Impaired acetylcholine-mediated vasodilation in obesity is not due to reduced responsiveness or increased cholinesterase activity. Arteriosclerosis, Thrombosis, and Vascular Biology. E16-E16. 2004
- Impaired endothelial fibrinolytic capacity with obesity is associated with oxidative stress. Arteriosclerosis, Thrombosis, and Vascular Biology. E40-E40. 2004
- Exercise without weight loss does not lower plasma C-reactive protein in obese adults. Federation proceedings. A1297-A1297. 2004
- Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy. Journal of applied physiology: respiratory, environmental and exercise physiology. 143-148. 2004
- Acute and chronic effects of oestrogen on endothelial tissue-type plasminogen activator release in postmenopausal women. Journal of Physiology. 721-728. 2003
- Endothelial release of tissue-type plasminogen activator in the human forearm: Role of nitric oxide. Journal of Cardiovascular Pharmacology. 311-314. 2003
- Obesity-related impairment in endothelial t-PA release is reversed with exercise. Arteriosclerosis, Thrombosis, and Vascular Biology. A22-A22. 2003
- Postmenopausal hormone replacement therapy and endothelial fibrinolytic capacity. Arteriosclerosis, Thrombosis, and Vascular Biology. A8-A9. 2003
- Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy. Journal of the American College of Cardiology. 283A-283A. 2003
- Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovascular Research. 861-868. 2003
- Short-term triglyceride lowering with fenofibrate improves vasodilator function in subjects with hypertriglyceridemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 307-313. 2003
- Effects of ageing and regular aerobic exercise on endothelial fibrinolytic capacity in humans. Journal of Physiology. 289-298. 2003
- Influence of oral contraceptive use on endothelial t-PA release in healthy premenopausal women. AJP - Endocrinology and Metabolism. E90-E95. 2003
- Decline in insulin action with age in endurance-trained humans. Journal of applied physiology: respiratory, environmental and exercise physiology. 2105-2111. 2002
- Regular aerobic exercise prevents and reverses the age-related decline in endothelial t-PA release. Circulation. 615-615. 2002
- Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. AJP - Heart and Circulatory Physiology. H1409-H1417. 2002
- Evidence for agonist-specific endothelial vasodilator dysfunction with ageing in healthy humans. Journal of Physiology. 255-262. 2002
- Age-related reductions in appendicular skeletal muscle mass: association with habitual aerobic exercise status. Clinical Physiology -Oxford-. 169-172. 2002
- Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. Journal of applied physiology: respiratory, environmental and exercise physiology. 1458-1464. 2002
- Capacity of the vascular endothelium to release tissue-type plasminogen activator declines with age in healthy adult humans. Federation proceedings. A436-A436. 2002
- Regular aerobic exercise restores the age-related reduction in central arterial compliance in postmenopausal women. Federation proceedings. A443-A443. 2002
- Pharmacologic versus flow-mediated assessments of peripheral vascular endothelial vasodilatory function in humans. American Journal of Cardiology. 1067-+. 2001
- Influence of regular aerobic exercise and hormone replacement therapy on carotid artery distensibility in postmenopausal women. Circulation. 526-527. 2001
- Triglyceride lowering with fenofibrate improves endothelial vasodilator function in patients with hypertriglyceridemia. Circulation. 240-240. 2001
- Maximal aerobic capacity across age in healthy Hispanic and Caucasian women. Journal of applied physiology: respiratory, environmental and exercise physiology. 1048-1054. 2001
- Blood pressure reductions with exercise and sodium restriction in postmenopausal women with elevated systolic pressure: Role of arterial stiffness. Journal of the American College of Cardiology. 506-513. 2001
- Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. AJP - Heart and Circulatory Physiology. H284-H289. 2001
- Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. Journal of Physiology. 287-295. 2001
- Femoral artery intima-media thickness: Influence of regular aerobic exercise and hormone replacement therapy. Federation proceedings. A791-A791. 2001
- Hypotensive effects of lifestyle interventions are associated with the corresponding chances in arterial stiffness. Federation proceedings. A792-A792. 2001
- Impaired endothelial vasodilator response to muscarinic but not beta-adrenoceptor stimulation in older men. Federation proceedings. A1127-A1127. 2001
- Lower circulating pro/anti-inflammatory cytokines in endurance-trained older men. Federation proceedings. A794-A794. 2001
- Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects. Journal of Physiology. 573-579. 2001
- Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men. Arteriosclerosis, Thrombosis, and Vascular Biology. 82-87. 2001
- Total and regional body composition across age in healthy Hispanic and white women of similar socioeconomic status. American Journal of Clinical Nutrition. 13-18. 2001
- Age-related declines in knee extensor strength and physical performance in healthy Hispanic and Caucasian women. Journals of Gerontology, Series A. B563-B569. 2000
- Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. Journal of Physiology. 263-271. 2000
- Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy adult humans. Circulation. 495-495. 2000
- Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 1351-1357. 2000
- Aging, habitual exercise, and dynamic arterial compliance. Circulation. 1270-1275. 2000
- Age, regular physical activity, and vagal baroreflex sensitivity in healthy men.. Federation proceedings. A384-A384. 2000
- Regular physical activity does not prevent or restore the age-related decline in limb blood flow.. Federation proceedings. A614-A614. 2000
- Reliability and validity of ultrasound-derived reactive hyperemia as a measure of endothelial function.. Federation proceedings. A400-A400. 2000
- Daily aerobic exercise improves tonic nitric oxide bioavailability in sedentary older men. Circulation. 829-829. 1999
- Moderate physical activity does not prevent age-related increase in central arterial stiffness in healthy men. Circulation. 523-523. 1999
- Regular aerobic exercise prevents and restores the age-related decline in endothelium-dependent vasodilation. Circulation. 796-796. 1999
- Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly. AJP - Heart and Circulatory Physiology. H947-H955. 1999
- Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly.. American Journal of Physiology. H947-H955. 1999
- Total blood volume in endurance-trained postmenopausal females: relation to exercise mode and maximal aerobic capacity. Acta Physiologica. 327-333. 1999
- Adiposity across age in healthy Hispanic and Caucasian women of similar socio-economic status.. Federation proceedings. A261-A261. 1999
- Tonic endothelial release of no: Influence of age and habitual physical activity.. Federation proceedings. A512-A512. 1999
- Hemodynamic sequelae of age-related increases in arterial stiffness in healthy women. American Journal of Cardiology. 1152-+. 1998
- Role of central circulatory factors in the fat-free mass-maximal aerobic capacity relation across age. AJP - Heart and Circulatory Physiology. H1178-H1182. 1998
- Role of central circulatory factors in the fat-free mass-maximal aerobic capacity relation across age.. American Journal of Physiology. H1178-H1182. 1998
- Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise. AJP - Endocrinology and Metabolism. E626-E634. 1998
- Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise.. American Journal of Physiology. E626-E634. 1998
- Arterial stiffness and hormone replacement use in healthy postmenopausal women. Journals of Gerontology, Series A. M344-M346. 1998
- Influence of body fatness on the coronary risk profile of physically active postmenopausal women. Metabolism. 1112-1120. 1998
- Elevated heart rate variability in physically active young and older adult women. Clinical Science. 579-584. 1998
- Arterial blood pressure reactivity to acute exercise is not related to habitual exercise status per se in healthy postmenopausal women. Federation proceedings. A1038-A1038. 1998
- Physical activity status does not affect age-related differences in insulin sensitivity in women. Federation proceedings. A365-A365. 1998
- Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arteriosclerosis, Thrombosis, and Vascular Biology. 362-368. 1998
- Absence of age-related increase in central arterial stiffness in physically active women. Arteriosclerosis, Thrombosis, and Vascular Biology. 127-132. 1998
- Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension. American Journal of Hypertension. 1335-1341. 1997
- Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension. American Journal of Hypertension. 1335-1341. 1997
- Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women. Journal of applied physiology: respiratory, environmental and exercise physiology. 1947-1953. 1997
- Physically active women demonstrate less adverse age-related changes in plasma lipids and lipoproteins. American Journal of Cardiology. 1360-&. 1997
- Regular exercise and the age-related decline in resting metabolic rate in women. The Journal of clinical endocrinology. 3208-3212. 1997
- Plasma fibrinogen levels in healthy postmenopausal women: Physical activity and hormone replacement status. Journals of Gerontology, Series A. M294-M298. 1997
- Systemic hemodynamic determinants of blood pressure in women: age, physical activity, and hormone replacement. AJP - Heart and Circulatory Physiology. H777-H785. 1997
- Systemic hemodynamic determinants of blood pressure in women: age, physical activity, and hormone replacement.. American Journal of Physiology. H777-H785. 1997
- Absence of age-related decline in total blood volume in physically active females. AJP - Heart and Circulatory Physiology. H2534-H2540. 1997
- Absence of age-related decline in total blood volume in physically active females.. American Journal of Physiology. H2534-H2540. 1997
- Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension.. Federation proceedings. 2696-2696. 1997
- Lack of age-related increase in central arterial stiffness in physically active women. Federation proceedings. 2829-2829. 1997
- Blood pressure risk factors in healthy postmenopausal women: Physical activity and hormone replacement. Journal of applied physiology: respiratory, environmental and exercise physiology. 652-660. 1997
- Treadmill aerobic exercise training reduces the energy expenditure and cardiovascular demands of hemiparetic gait in chronic stroke patients - A preliminary report. Stroke. 326-330. 1997
- Effects of chromium and resistive training on muscle strength and body composition. Medicine and science in sports. 139-144. 1996

Background

education and training

Ph.D., University of Maryland College Park Campus 1995
M.A., George Washington University 1991
B.A., Univ of Toronto (Canada) 1988

awards and honors

Young Investigator Awards (Society for Experimental Biology and Medicine), conferred by Society for Experimental Biology and Medicine, 1998

International Activities

global connections related to teaching and scholarly work (in recent years)

Canada Country

Other Profiles

ORCID iD

http://orcid.org/0000-0001-9372-5083