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Publications in VIVO

Wuttke, Deborah S Professor


Research Areas research areas


research overview

  • One goal of my lab is to define the mechanism by which telomeres mediate chromosomal end protection and telomerase action using structural and biochemical tools. Understanding the mechanism of telomere maintenance is important in understanding the complex biological processes of cancer and aging. This has included detailed characterization of the proteins that bind the conserved single-stranded overhang at telomeres to understand both how their unique affinities and specificities are achieved as well as the biological roles for these activities. In the course of these studies, we have identified novel implementations of plasticity in recognition. The study of the mechanisms underlying this malleability have become related focus of our lab. A second goal of my lab is to understand the protein interactions that mediate the activities of long non-coding RNAs. It has come as a huge surprise that the majority of the human genome is actively transcribed.


  • structural biology, telomere and telomerase, ssDNA, protein, long non-coding RNA and non-canonical protein, RNA interactions, molecular recognition


selected publications


courses taught

  • BCHM 4761 - Biochemistry Laboratory
    Primary Instructor - Fall 2019
    Two 4-hour periods per week. Introduction to modern biochemical techniques. Topics include enzymology, spectrophotometry, electrophoresis, multi-step protein purification, recombinant DNA techniques and molecular cloning. Formerly CHEM 4761.
  • BCHM 5781 - Advanced General Biochemistry 2
    Primary Instructor - Spring 2021
    Lect. Detailed consideration of contemporary topics in biochemistry, including protein structure (primary, secondary, tertiary, and quaternary), methods of structure determination and prediction, protein folding (kinetics, thermodynamics, denaturation, and renaturation), and protein dynamics (internal motions and methods of analysis). Formerly CHEM 5781.
  • BCHM 6901 - Research in Biochemistry
    Primary Instructor - Fall 2019 / Spring 2020 / Fall 2020 / Spring 2021
    May be repeated up to 15 total credit hours.
  • CHEM 4400 - Core Concepts in Physical Chemistry for Biochemists
    Primary Instructor - Spring 2018
  • CHEM 5781 - Advanced General Biochemistry 2
    Primary Instructor - Spring 2019
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Fall 2018 / Spring 2019
    May be repeated up to 15 total credit hours.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Fall 2021
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. May be repeated up to 15 total credit hours.


International Activities

global connections related to teaching and scholarly work (in recent years)

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