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Publications in VIVO
 

Wuttke, Deborah S Professor

Positions

Research Areas research areas

Research

research overview

  • One goal of my lab is to define the mechanism by which telomeres mediate chromosomal end protection and telomerase action using structural and biochemical tools. Understanding the mechanism of telomere maintenance is important in understanding the complex biological processes of cancer and aging. This has included detailed characterization of the proteins that bind the conserved single-stranded overhang at telomeres to understand both how their unique affinities and specificities are achieved as well as the biological roles for these activities. In the course of these studies, we have identified novel implementations of plasticity in recognition. The study of the mechanisms underlying this malleability have become related focus of our lab. A second goal of my lab is to understand the protein interactions that mediate the activities of long non-coding RNAs. It has come as a huge surprise that the majority of the human genome is actively transcribed.

keywords

  • structural biology, telomere and telomerase, ssDNA, protein, long non-coding RNA and non-canonical protein, RNA interactions, molecular recognition

Publications

selected publications

Teaching

courses taught

  • BCHM 4400 - Core Concepts in Physical Chemistry for Biochemists
    Primary Instructor - Spring 2018
    Introduces thermodynamics, kinetics and spectroscopy, emphasizing macromolecule and biochemical applications. Includes thermodynamics, chemical and physical equilibriums, solution chemistry, rates of chemical and biochemical reactions, chemical bonds and principles and selected examples of spectroscopies applied to biological systems. Department enforced prerequisite or corequisite: PHYS 1120 or PHYS 2020. Formerly CHEM 4411. Same as BCHM 5400 and CHEM 4511.
  • BCHM 4761 - Biochemistry Laboratory
    Primary Instructor - Fall 2019
    Two 4-hour periods per week. Introduction to modern biochemical techniques. Topics include enzymology, spectrophotometry, electrophoresis, multi-step protein purification, recombinant DNA techniques and molecular cloning. Formerly CHEM 4761.
  • BCHM 5400 - Core Concepts in Physical Chemistry for Biochemists
    Primary Instructor - Spring 2018
    Introduces thermodynamics, kinetics and spectroscopy, emphasizing macromolecule and biochemical applications. Includes thermodynamics, chemical and physical equilibriums, solution chemistry, rates of chemical and biochemical reactions, chemical bonds and principles and selected examples of spectroscopies applied to biological systems. Formerly CHEM 5411. Same as BCHM 4400 and CHEM 4511.
  • BCHM 6901 - Research in Biochemistry
    Primary Instructor - Fall 2019 / Spring 2020
    Research in Biochemistry
  • CHEM 5780 - Fundamentals of Biochemistry II
    Primary Instructor - Spring 2019
    Analysis of topics in biochemistry including protein structure, methods of structure determination and prediction, protein folding, and protein dynamics. Intended as a comprehensive treatment of areas central to modern biochemistry for entering graduate students. Lectures concurrent with CHEM 5781, covering the same topics except for the requirement of a written research proposal. Formerly CHEM 5780.
  • CHEM 5781 - Advanced General Biochemistry 2
    Primary Instructor - Spring 2019
    Lect. Detailed consideration of contemporary topics in biochemistry, including protein structure (primary, secondary, tertiary, and quaternary), methods of structure determination and prediction, protein folding (kinetics, thermodynamics, denaturation, and renaturation), and protein dynamics (internal motions and methods of analysis). Formerly CHEM 5781.
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Spring 2020
    May be repeated up to 15 total credit hours.

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

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