Journal of Pharmaceutical Sciences
Overview
publication venue for
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Formulation of three tailed bacteriophages by spray-drying and atomic layer deposition for thermal stability and controlled release.
2024
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Stabilization of an Infectious Enveloped Virus by Spray-Drying and Lyophilization.
2024
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Stain-Free Approach to Determine and Monitor Cell Heath Using Supervised and Unsupervised Image-Based Deep Learning
2024
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Features in Backgrounds of Microscopy Images Introduce Biases in Machine Learning Analyses
2024
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Interfacial Adsorption Controls Particle Formation in Antibody Formulations Subjected to Extensional Flows and Hydrodynamic Shear
2023
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A Single Dose, Thermostable, Trivalent Human Papillomavirus Vaccine Formulated Using Atomic Layer Deposition
2023
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Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates
2022
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Machine Learning Analysis Provides Insight into Mechanisms of Protein Particle Formation Inside Containers During Mechanical Agitation
2022
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Atomic-Layer Deposition Processes Applied to Phage lambda and a Phage-like Particle Platform Yield Thermostable, Single-Shot Vaccines
2022
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An Interlaboratory Comparison on the Characterization of a Sub-micrometer Polydisperse Particle Dispersion
2022
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Machine learning and accelerated stress approaches to differentiate potential causes of aggregation in polyclonal antibody formulations during shipping
2021
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Preservation of Quaternary Structure in Thermostable, Lyophilized Filovirus Glycoprotein Vaccines: A Search for Stability-Indicating Assays
2020
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Aggregation and Particle Formation During Pumping of an Antibody Formulation Are Controlled by Electrostatic Interactions Between Pump Surfaces and Protein Molecules
2020
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Container Surfaces Control Initiation of Cavitation and Resulting Particle Formation in Protein Formulations After Application of Mechanical Shock
2020
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DEHP Nanodroplets Leached From Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum
2020
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Nanobubbles in Reconstituted Lyophilized Formulations: Interaction With Proteins and Mechanism of Formation
2020
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Subvisible Particles in IVIg Formulations Activate Complement in Human Serum
2020
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Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions
2019
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Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations
2019
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Steric Repulsion Forces Contributed by PEGylation of Interleukin-1 Receptor Antagonist Reduce Gelation and Aggregation at the Silicone Oil-Water Interface
2019
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Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues
2018
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Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations
2018
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Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses
2018
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Flow Microscopy Imaging Is Sensitive to Characteristics of Subvisible Particles in Peginesatide Formulations Associated With Severe Adverse Reactions
2018
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Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations
2018
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Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models
2017
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Microflow Imaging Analyses Reflect Mechanisms of Aggregate Formation: Comparing Protein Particle Data Sets Using the Kullback-Leibler Divergence
2017
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Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions
2016
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Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces
2016
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Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20
2016
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Formation of Stable Nanobubbles on Reconstituting Lyophilized Formulations Containing Trehalose
2016
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Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges
2016
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Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice
2016
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Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes
2015
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The Role of Protein Excipient in Driving Antibody Responses to Erythropoietin
2015
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In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations
2015
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Analysis of Diffusion-Controlled Dissolution from Polydisperse Collections of Drug Particles with an Assessed Mathematical Model.
2015
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Hydrodynamic Effects on Drug Dissolution and Deaggregation in the Small Intestine-A Study with Felodipine as a Model Drug.
2015
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Dose Levels in Particulate-Containing Formulations Impact Anti-drug Antibody Responses to Murine Monoclonal Antibody in Mice
2015
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Effect of the Siliconization Method on Particle Generation in a Monoclonal Antibody Formulation in Pre-filled Syringes
2015
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Gelation of a Monoclonal Antibody at the Silicone Oil-Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation
2015
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Do Not Drop: Mechanical Shock in Vials Causes Cavitation, Protein Aggregation, and Particle Formation
2015
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Glassy-State Stabilization of a Dominant Negative Inhibitor Anthrax Vaccine Containing Aluminum Hydroxide and Glycopyranoside Lipid A Adjuvants
2015
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The Effect of Protein PEGylation on Physical Stability in Liquid Formulation
2014
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Effects of Phenol and meta-Cresol Depletion on Insulin Analog Stability at Physiological Temperature
2014
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Freezing-Induced Perturbation of Tertiary Structure of a Monoclonal Antibody
2014
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Protein Aggregation and Particle Formation in Prefilled Glass Syringes
2014
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Protein Quantity on the Air-Solid Interface Determines Degradation Rates of Human Growth Hormone in Lyophilized Samples
2014
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Investigations into the Fouling Mechanism of Parvovirus Filters During Filtration of Freeze-Thawed mAb Drug Substance Solutions
2014
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Albinterferon alpha(2b) Adsorption to Silicone Oil-Water Interfaces: Effects on Protein Conformation, Aggregation, and Subvisible Particle Formation
2014
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Antibody Responses in Mice to Particles Formed from Adsorption of a Murine Monoclonal Antibody onto Glass Microparticles
2014
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Preformulation Study of Highly Purified Inactivated Polio Vaccine, Serotype 3
2014
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Recombinant Murine Growth Hormone Particles are More Immunogenic with Intravenous than Subcutaneous Administration
2014
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The effects of excipients on protein aggregation during agitation: An interfacial shear rheology study
2013
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IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: A model for siliconized primary containers
2013
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Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation
2013
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Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces
2013
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Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions
2012
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Particles shed from syringe filters and their effects on agitation-induced protein aggregation
2012
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Physical stability of albinterferon-alpha(2b) in aqueous solution: Effects of conformational stability and colloidal stability on aggregation
2012
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Accelerated Stability Studies of Abatacept Formulations: Comparison of Freeze-Thawing- and Agitation-Induced Stresses
2012
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Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate
2012
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Selective domain stabilization as a strategy to reduce fusion protein aggregation
2012
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The role of adjuvant in mediating antigen structure and stability
2012
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Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release
2012
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Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene
2012
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Glass Particles as an Adjuvant: A Model for Adverse Immunogenicity of Therapeutic Proteins
2011
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Effect of Benzyl Alcohol on Recombinant Human Interleukin-1 Receptor Antagonist Structure and Hydrogen-Deuterium Exchange
2011
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Effects of Surfaces and Leachables on the Stability of Biopharmaceuticals
2011
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Aggregation of Recombinant Human Botulinum Protein Antigen Serotype C in Varying Solution Conditions: Implications of Conformational Stability for Aggregation Kinetics
2011
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Subvisible Particle Counting Provides a Sensitive Method of Detecting and Quantifying Aggregation of Monoclonal Antibody Caused by Freeze-Thawing: Insights Into the Roles of Particles in the Protein Aggregation Pathway
2011
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Adsorption of Monoclonal Antibodies to Glass Microparticles
2011
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Buffer-Dependent Fragmentation of a Humanized Full-Length Monoclonal Antibody
2010
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Potential Inaccurate Quantitation and Sizing of Protein Aggregates by Size Exclusion Chromatography: Essential Need to Use Orthogonal Methods to Assure the Quality of Therapeutic Protein Products
2010
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Protein Adsorption and Excipient Effects on Kinetic Stability of Silicone Oil Emulsions
2010
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Inhibition of Agitation-Induced Aggregation of an IgG-Antibody by Hydroxypropyl-β-Cyclodextrin
2010
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Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation
2010
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Evaluation of Chemical Degradation of a Trivalent Recombinant Protein Vaccine Against Botulinum Neurotoxin by LysC Peptide Mapping and MALDI-TOF Mass Spectrometry
2009
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Immunogenicity of Aggregates of Recombinant Human Growth Hormone in Mouse Models
2009
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Mixing Properties of Lyophilized Protein Systems: A Spectroscopic and Calorimetric Study
2009
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Monoclonal Antibody Interactions With Micro- and Nanoparticles: Adsorption, Aggregation, and Accelerated Stress Studies
2009
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Precipitation of a Monoclonal Antibody by Soluble Tungsten
2009
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Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution
2009
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Stability of a Trivalent Recombinant Protein Vaccine Formulation Against Botulinum Neurotoxin During Storage in Aqueous Solution
2009
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Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality
2009
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Common Excipients Impair Detection of Protein Aggregates during Sedimentation Velocity Analytical Ultracentrifugation
2009
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IgG Particle Formation during Filling Pump Operation: A Case Study of Heterogeneous Nucleation on Stainless Steel Nanoparticles
2009
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Influence of Protein Conformation and Adjuvant Aggregation on the Effectiveness of Aluminum Hydroxide Adjuvant in a Model Alkaline Phosphatase Vaccine
2009
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Effect of pH on Stability of Recombinant Botulinum Serotype A Vaccine in Aqueous Solution and During Storage of Freeze-Dried Formulations
2008
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Influence of Particle Size and Antigen Binding on Effectiveness of Aluminum Salt Adjuvants in a Model Lysozyme Vaccine
2008
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High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization
2008
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High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics
2008
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Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying
2008
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Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing
2008
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Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry
2008
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Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt Adjuvants
2007
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Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity
2007
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Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor
2006
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Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist
2005
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Supercritical fluid crystallization of griseofulvin: Crystal habit modification with a selective growth inhibitor
2005
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Effects of Tween 20® and Tween 80® on the stability of albutropin during agitation
2005
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Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations
2005
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Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation
2005
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Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution
2004
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Degradation kinetics of high molecular weight poly (L-lactide) microspheres and release mechanism of lipid : DNA complexes
2004
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Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations
2004
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Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures
2004
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Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-γ
2003
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Hydrophobic ion pairing of isoniazid using a prodrug approach
2002
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Surface adsorption of recombinant human interferon-γ in lyophilized and spray-lyophilized formulations
2002
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A new mechanism for decreasing aggregation of recombinant human interferon-γ by a surfactant:: Slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20
2002
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The effects of tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution
2001
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Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine Tg��� in pharmaceutical lyophilization
2001
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The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf
2001
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Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO2-assisted aerosolization
2001
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Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor
2000
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Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran
2000
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Photopolymerized, multilaminated matrix devices with optimized nonuniform initial concentration profiles to control drug release
2000
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Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid
1999
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Conformational stability of lyophilized PEGylated proteins in a phase-separating system
1999
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Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant, human factor XIII
1998
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Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions
1998
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Aggregation of recombinant human interferon gamma: Kinetics and structural transitions
1998
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Effects of tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin
1998
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Preparation and in vitro characterization of gentamycin-impregnated biodegradable beads suitable for treatment of osteomyelitis
1998
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Phase separation of excipients during lyophilization: Effects on protein stability
1997
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Effects of phase separating systems on lyophilized hemoglobin
1996
Research
keywords
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1115 Pharmacology and Pharmaceutical Sciences