research overview
- Biochemistry and nucleic acid chemistry
- Contact Info
Caruthers, Marvin H
Positions
- Distinguished Professor, Biochemistry
Research Areas
Research
Publications
selected publications
-
chapter
- DNA Synthesis for Nonchemists - The Phosphoramidite Method on Silica Supports 2012
- Synthesis of DNA Using a New Two-Step Cycle 2005
- Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method. 1-20. 2000
- Modified Oligodeoxynucleotides as Antisense Therapeutics. 51-71. 1998
- The Chemical Synthesis of DNA/RNA 1996
- SYNTHESIS AND BIOLOGICAL STUDIES WITH DNA ANALOGS. 191-198. 1994
- Synthesis of Oligonucleotides and Oligonucleotide Analogs on Polymer Supports 1994
- Studies on Nucleotide Chemistry XXXVII. Synthesis and Purification of Phosphorodithioate DNA 1993
- Studies on Nucleotide Chemistry XXXV. Synthesis of Oligonucleotide Phosphorodithioates 1991
- SYNTHESIS AND BIOCHEMICAL-STUDIES OF DNA ANALOGS. 199-208. 1990
- Synthesis of DNA, RNA, and Biochemically Interesting Analogs 1989
- Synthesis of Oligonucleotides and Oligonucleotide Analogs 1989
- Synthesis of DNA on Silica Surfaces 1988
- The Thymine 5-Methyl Group: A Protein-DNA Contact Site Useful for Redesigning Cro Repressor to Recognize a New Operator 1988
- A New Method for Synthesizing RNA on Silica Supports 1987
- DNA Synthesis as an Aid to Protein Modification and Design 1987
- Protein-DNA Recognition: The Interaction of lac, cI and E. coli RNA Polymerase with Operators and Promoters 1987
- Studies on Nucleotide Chemistry XIX. Synthesis of Oligonucleotides Using the Phosphoramidite Method 1987
- Improved Parameters for Prediction of RNA Secondary Structure and Insights into Why RNA Forms Double Helixes 1986
- Studies on Gene Control Regions XIX. The Interaction of Cro, cI, and Escherichia coli RNA Polymerase with Operators and Promoters 1986
- Polymer Supported Polynucleotide Synthesis and Applications to Molecular Biology 1985
- Ribosome Binding Site Sequences and Function 1985
- Gene Synthesis-Toward a Future World 1984
- Chemical and Biochemical Studies on Gene Control Regions 1983
- New Methods for Chemically Synthesizing Deoxyoligonucleotides 1983
- Synthesis of Oliogodeoxynucleotides Using the Phosphoramidite Method 1983
- Studies on Nucleotide IX. The Synthesis and Biochemical Reactivity of Biologically Important Genes and Gene Control Regions 1982
- Chemical Synthesis of Oligodeoxynucleotides Using the Phosphite Triester Intermediates 1982
- Studies on Gene Control Regions XIII. Chemical Synthesis and Biological Studies on Mutated Gene Control Regions 1982
- Studies on Nucleotide Chemistry VI. New Methods of Synthesizing Promoters and Other Gene Control Regions 1982
- Studies on Nucleotide Chemistry VIII. New Methods for Synthesizing Deoxyoligonucleotides 1982
- Synthesis of Sequence Defined Polynucleotides via Diester, Triester and Phosphite Coupling Methods 1981
- Synthesis of Lac and Lambda Operator DNA Sequences 1976
- Current Work on the Synthesis of Transfer RNA Genes 1973
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conference proceeding
- Boranephosphonate DNA: Intermediates in the synthesis of internucleotide phosphate analogs. ACS National Meeting Book of Abstracts. 2014
- Award Address (ACS Award for Creative Invention sponsored by ACS Corporation Associates). Chemical synthesis, biochemistry, and biological activity of long DNAs/RNAs and their analogs. ACS National Meeting Book of Abstracts. 2014
- Oligonucleotide synthesis interfaced with molecular biology. The Federation of European Biochemical Societies (FEBS) Journal. 78-78. 2013
- SYNTHESIS AND BIOCHEMICAL-STUDIES OF DITHIOATE DNA. 158-168. 1990
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journal article
-
Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-in-Sarcoma Amyotrophic Lateral Sclerosis..
International Journal of Molecular Sciences.
2024
-
Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids.
Nucleic Acid Therapeutics.
2024
-
Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry.
Molecules.
2023
-
Report Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression.
Cell Reports.
2023
-
Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing.
Proceedings of the National Academy of Sciences of USA.
2022
-
Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention.
Nature Communications.
2021
-
DNA Analogues Modified at the Nonlinking Positions of Phosphorus.
Accounts of Chemical Research.
2152-2166.
2020
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Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras.
Journal of the American Chemical Society.
16240-16253.
2020
-
Synthesis of Small-Molecule/DNA Hybrids through On-Bead Amide-Coupling Approach.
Journal of Organic Chemistry.
10803-10811.
2017
-
Oxidative Substitution of Boranephosphonate Diesters as a Route to Post-synthetically Modified DNA (vol 137, pg 3253, 2015).
Journal of the American Chemical Society.
13586-13586.
2017
-
Silver Nanoassemblies Constructed from Boranephosphonate DNA (vol 135, pg 6234, 2013).
Journal of the American Chemical Society.
13585-13585.
2017
-
Oligodeoxynucleotides containing 2 '-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers.
Bioorganic and Medicinal Chemistry Letters.
3173-3176.
2017
-
Pyridinium Boranephosphonate Modified DNA Oligonucleotides (vol 82, pg 1420, 2017).
Journal of Organic Chemistry.
5506-5506.
2017
-
Boranephosphonate DNA-Mediated Metallization of Single-Walled Carbon Nanotubes.
Chemistry of Materials.
2239-2245.
2017
-
Pyridinium Boranephosphonate Modified DNA Oligonucleotides.
Journal of Organic Chemistry.
1420-1427.
2017
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Synthesis of Phosphorodiamidate Morpholino Oligonucleotides and Their Chimeras Using Phosphoramidite Chemistry (Retracted article. See vol. 141, pg. 9430, 2019).
Journal of the American Chemical Society.
15663-15672.
2016
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Peptide-substituted oligonucleotide synthesis and non-toxic, passive cell delivery.
Signal Transduction and Targeted Therapy.
2016
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Solid-Phase Synthesis, Hybridizing Ability, Uptake, and Nuclease Resistant Profiles of Position-Selective Cationic and Hydrophobic Phosphotriester Oligonucleotides.
Journal of Organic Chemistry.
9147-9158.
2015
-
Correction to "Oxidative Substitution of Boranephosphonate Diesters as a Route to Post-synthetically Modified DNA"..
Journal of the American Chemical Society.
10016.
2015
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Formation of Silver Nanostructures by Rolling Circle Amplification Using Boranephosphonate-Modified Nucleotides.
Analytical Chemistry.
6660-6666.
2015
-
Oxidative Substitution of Boranephosphonate Diesters as a Route to Post-synthetically Modified DNA.
Journal of the American Chemical Society.
3253-3264.
2015
-
Robert Letsinger: The father of synthetic DNA chemistry.
Proceedings of the National Academy of Sciences of USA.
18098-18099.
2014
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Effect of 2'-O-methyl/thiophosphonoacetate-modified antisense oligonucleotides on huntingtin expression in patient-derived cells..
Artificial DNA: PNA and XNA.
e1146391.
2014
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Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries.
Molecules.
14268-14284.
2013
-
Silver Nanoassemblies Constructed from Boranephosphonate DNA.
Journal of the American Chemical Society.
6234-6241.
2013
-
The Chemical Synthesis of DNA/RNA: Our Gift to Science.
Journal of Biological Chemistry.
1420-1427.
2013
-
Gene Synthesis with H G Khorana.
Resonance.
1143-1156.
2012
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Alkynyl Phosphonate DNA: A Versatile "Click"able Backbone for DNA-Based Biological Applications.
Journal of the American Chemical Society.
11618-11631.
2012
-
Reduction of metal ions by boranephosphonate DNA.
Organic and Biomolecular Chemistry.
9130-9133.
2012
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Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2′-O-methyl oligoribonucleotides.
Organic and Biomolecular Chemistry.
746-754.
2012
- Reduction of metal ions by boranephosphonate DNA: Potential applications from nanotechnology to biosensing. ACS National Meeting Book of Abstracts. 2011
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Streamlined Process for the Chemical Synthesis of RNA Using 2′-O-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase.
Journal of the American Chemical Society.
11540-11556.
2011
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Solid-Phase Synthesis, Thermal Denaturation Studies, Nuclease Resistance, and Cellular Uptake of (Oligodeoxyribonucleoside)methylborane Phosphine-DNA Chimeras.
Journal of the American Chemical Society.
9844-9854.
2011
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A brief review of DNA and RNA chemical synthesis.
Biochemical Society Transactions.
575-580.
2011
- Har Gobind Khorana. Science. 1511-1511. 2011
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SYNTHESIS AND BIOLOGICAL ACTIVITY OF BORANE PHOSPHONATE DNA.
Phosphorus Sulfur and Silicon and the Related Elements.
921-932.
2011
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Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process.
Nucleic Acids Research.
2522-2540.
2010
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Synthesis of (pentacarbonyl)tungstate(-1) and (pentacarbonyl)molybdate(-1) dinucleotides.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
5015-5017.
2009
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Synthesis and biochemical activity of new oligonucleotide analogs.
Phosphorus Sulfur and Silicon and the Related Elements.
349-363.
2008
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An electrospray mass spectrometric method for accurate mass determination of highly acid-sensitive phosphoramidites.
Rapid Communications in Mass Spectrometry.
533-540.
2008
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Synthesis and biological activity of phosphonocarboxylate DNA.
Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication.
539-546.
2007
-
Synthesis of mixed sequence borane phosphonate DNA.
Journal of the American Chemical Society.
8138-8139.
2006
-
Synthesis of mixed sequence borane phosphonate DNA..
Journal of the American Chemical Society.
8138-8139.
2006
-
Synthesis and biochemical evaluation of phosphonoformate oligodeoxyribonucleotides.
Journal of the American Chemical Society.
5251-5261.
2006
-
Accurate mass analysis of phosphoramidites by electrospray mass spectrometry.
Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication.
663-666.
2005
-
New methods for synthesizing DNA, RNA, and phosphonates.
Chimia.
39-42.
2005
-
Oligodeoxyribonucleotide analogs functionalized with phosphonoacetate and thiophosphonoacetate diesters..
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].
Unit-4.24.
2004
-
Solid-phase oligodeoxynucleotide synthesis: A two-step cycle using peroxy anion deprotection.
Journal of the American Chemical Society.
13427-13441.
2003
-
Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides.
Nucleic Acids Research.
4109-4118.
2003
-
Solid-phase chemical synthesis of phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides.
Journal of the American Chemical Society.
940-950.
2003
-
Solid-phase synthesis and biochemical studies of O-boranophosphopeptides and O-dithiophosphopeptides.
Journal of the American Chemical Society.
6584-6593.
2002
-
Chemical synthesis of an oligodeoxythymidylate containing boranephosphate and phosphate linkages.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
749-751.
2002
-
The Tetrahymena ribozyme cleaves a 5′-methylene phosphonate monoester ∼102-fold faster than a normal phosphate diester:: Implications for enzyme catalysis of phosphoryl transfer reactions.
Biochemistry.
10911-10926.
2001
-
Hammerhead cleavage of the phosphorodithioate linkage.
Biochemistry.
4947-4954.
2000
-
Synthesis of phosphorodithioate DNA by the H-phosphonothioate method.
Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr.
5759-5772.
1999
-
Novel RNA synthesis method using 5′-O-silyl-2′-O-orthoester protecting groups.
Journal of the American Chemical Society.
11820-11821.
1998
-
Synthesis of an oligothymidylate containing boranophosphate linkages.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
3899-3902.
1998
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Interactions between single-stranded DNA binding protein and oligonucleotide analogs with different backbone chemistries.
Journal of Molecular Recognition.
101-107.
1997
- Comparative Pharmacokinetics, Tissue Distribution and Tumor Accumulation of Phosphorothioate, Phosphorodithioate and Methylphosphonate Deoxyoligonucleotide Analogues in Nude Mice. Nucleic Acid Therapeutics. 71-77. 1997
- Hepatic Distribution and Clearance of Antisense Oligonucleotides in the Isolated Perfused Rat Liver. Pharmaceutical Research. 1997
- Oligonucleotides as therapeutic agents - Introduction. Ciba Foundation symposium. 1-4. 1997
- Oligonucleotides as therapeutic agents - Summary. Ciba Foundation symposium. 235-239. 1997
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Inhibition of the erB-2 tyrosine kinase receptor in breast cancer cells by phosphoromonothioate and phosphorodithioate antisense oligonucleotides.
Nucleic Acids Research.
4558-4564.
1996
- Toward antibody mediated nucleic acid detection.. Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine. 49-49. 1996
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5'-dithiophosphoryl deoxyoligonucleotides: Synthesis and biological studies.
Journal of the American Chemical Society.
9562-9566.
1996
-
Synthesis of 5'-phosphonate linked thymidine deoxyoligonucleotides.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
6457-6460.
1996
-
Synthesis and preliminary biochemical studies with 5'-deoxy-5'-methylidyne phosphonate linked thymidine oligonucleotides.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
6239-6242.
1996
-
Biochemical and physicochemical properties of phosphorodithioate DNA.
Biochemistry.
8734-8741.
1996
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Synthesis of phosphorodithioate DNA via sulfur-linked, base-labile protecting groups.
Journal of Organic Chemistry.
4272-4281.
1996
-
Synthesis of phosphorodithioate RNA by the H-phosphonothioate method.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
4451-4454.
1996
- SYNTHESIS OF A DINUCLEOTIDE PHOSPHORAMIDIMIDATE. Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry. 6807-6810. 1995
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STEREOSELECTIVE SYNTHESIS, CHEMISTRY AND ANTIVIRAL EVALUATION OF 1-(2,3-DIDEOXY-3-C-HYDROXYMETHYL-BETA-D-THREO-PENTOFURANOSYL)THYMINE DERIVATIVES.
Bioorganic and Medicinal Chemistry.
1223-1229.
1995
-
ANTISENSE DNA DOWN-REGULATION OF THE ERBB2 ONCOGENE MEASURED BY A FLOW CYTOMETRIC ASSAY.
Proceedings of the National Academy of Sciences of USA.
8338-8342.
1995
-
2'-DEOXYNUCLEOSIDE DITHIOPHOSPHATES - SYNTHESIS AND BIOLOGICAL STUDIES .39..
Journal of the American Chemical Society.
1472-1478.
1995
-
OXIDATIVE FORMATION OF PHOSPHORODITHIOATES VIA H-PHOSPHONODITHIOATES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
695-698.
1995
-
CELLULAR PHARMACOLOGY AND PROTEIN-BINDING OF PHOSPHOROMONOTHIOATE AND PHOSPHORODITHIOATE OLIGODEOXYNUCLEOTIDES - A COMPARATIVE-STUDY.
Antisense research and development.
269-278.
1994
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SYNTHESIS OF DINUCLEOSIDE PHOSPHORAMIDIMIDATES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
2941-2944.
1994
- 2'-DEOXY-NUCLEOSIDE-DITHIOMONOPHOSPHATES - SYNTHESIS AND BIOLOGICAL STUDIES. ACS National Meeting Book of Abstracts. 5-MEDI. 1994
- USE OF SINGLE PHOSPHORODITHIOATE LINKAGES IN DUPLEX DNA TO STUDY DUPLEX STRUCTURE IN PROTEIN/DNA COMPLEXES. Journal of Cellular Biochemistry. 147-147. 1994
-
NUCLEOTIDE CHEMISTRY .38. SYNTHESIS OF 5'-DEOXY-5'-METHYLPHOSPHONATE LINKED THYMIDINE OLIGONUCLEOTIDES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
2723-2726.
1993
- SYNTHESIS, BIOCHEMISTRY, AND BIOLOGICAL APPLICATIONS OF NEW POLYNUCLEOTIDE ANALOGS. Journal of Cellular Biochemistry. 190-190. 1993
- SYNTHESIS, BIOCHEMISTRY, AND BIOLOGICAL APPLICATIONS OF NEW POLYNUCLEOTIDE ANALOGS. ACS National Meeting Book of Abstracts. 8-MEDI. 1993
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PHOSPHORODITHIOATE DNA AS A POTENTIAL THERAPEUTIC DRUG.
Science.
1564-1569.
1993
- 2 APPROACHES TO THE LARGE-SCALE SYNTHESIS OF OLIGONUCLEOTIDE DITHIOATES. Bioorganicheskaia khimiia. 211-222. 1993
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METAL-ION CATALYSIS IN THE TETRAHYMENA RIBOZYME REACTION.
Nature.
85-88.
1993
-
Synthesis and purification of phosphorodithioate DNA..
Methods in Molecular Biology.
191-206.
1993
-
INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS ACTIVITY BY PHOSPHORODITHIOATE OLIGODEOXYCYTIDINE.
Proceedings of the National Academy of Sciences of USA.
6265-6269.
1992
- PHOSPHORODITHIOATE DNA AS A POTENTIAL THERAPEUTIC DRUG. ACS National Meeting Book of Abstracts. 32-BTEC. 1992
- CHEMICAL SYNTHESIS OF DEOXYOLIGONUCLEOTIDES AND DEOXYOLIGONUCLEOTIDE ANALOGS. Methods in Enzymology. 3-20. 1992
- PHOSPHATE RECOGNITION BY A RIBOZYME. The FASEB Journal. A412-A412. 1992
-
CHEMICAL SYNTHESIS OF DNA AND DNA ANALOGS.
Accounts of Chemical Research.
278-284.
1991
-
DETECTION AND CHARACTERIZATION OF A FACTOR WHICH RESCUES SPLICEOSOME ASSEMBLY FROM A HEAT-INACTIVATED HELA-CELL NUCLEAR EXTRACT.
Molecular and Cellular Biology.
3425-3431.
1991
-
SYNTHESIS OF DEOXYDINUCLEOSIDE PHOSPHORODITHIOATES.
Journal of the American Chemical Society.
3972-3980.
1991
-
SYNTHESIS OF OLIGONUCLEOTIDE PHOSPHORODITHIOATES.
Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr.
2377-2388.
1991
-
CHEMICAL AND BIOCHEMICAL-STUDIES WITH DITHIOATE DNA.
Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication.
47-59.
1991
- SYNTHESIS AND BIOCHEMICAL-STUDIES OF DITHIOATE DNA. Ciba Foundation symposium. 158-168. 1991
- Synthesis and biological studies with dithioate DNA.. Nucleic Acids Symposium Series. 91-94. 1991
-
ROLE OF THE CRO REPRESSOR CARBOXY-TERMINAL DOMAIN AND FLEXIBLE DIMER LINKAGE IN OPERATOR AND NONSPECIFIC DNA-BINDING.
Biochemistry.
9241-9249.
1990
-
ANTIBODIES SPECIFIC FOR BRANCHED RIBONUCLEIC-ACIDS.
Analytical Biochemistry.
125-130.
1990
-
O-ARYL PHOSPHORAMIDITES - SYNTHESIS, REACTIVITY AND EVALUATION OF THEIR USE FOR SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES.
Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr.
721-730.
1990
-
SYNTHESIS OF DINUCLEOSIDE AND DINUCLEOTIDE PHOSPHORODITHIOATES VIA A PHOSPHOTRIESTER APPROACH.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
1953-1956.
1990
-
STRUCTURE OF S-PHENYL O-3'-THYMIDINYL METHYLPHOSPHONOTHIOATE .27. NUCLEOTIDE CHEMISTRY.
Acta Crystallographica Section C: Crystal Structure Communications.
1639-1641.
1989
-
CHEMICAL SYNTHESIS OF DNA.
Journal of Chemical Education.
577-580.
1989
-
SYNTHESIS OF OLIGODEOXYNUCLEOSIDE PHOSPHORODITHIOATES VIA THIOAMIDITES.
Journal of the American Chemical Society.
2321-2322.
1989
-
NUCLEOTIDE CHEMISTRY .30. OXIDATIVE AND NONOXIDATIVE FORMATION OF INTERNUCLEOTIDE LINKAGES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
6621-6624.
1989
-
SYNTHESIS OF DEOXYCYTIDINE OLIGOMERS CONTAINING PHOSPHORODITHIOATE LINKAGES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
543-546.
1989
-
SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING SPECIFIC METHYLPHOSPHONOTHIOATE AND DITHIOATE MOIETIES.
Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication.
1011-1014.
1989
- Synthesis of oligodeoxynucleoside phosphorodithioates.. Nucleic Acids Symposium Series. 119-120. 1989
-
DIRECTED ARBUZOV-TYPE REACTIONS OF 2-CYANO-1,1-DIMETHYLETHYL DEOXYNUCLEOSIDE PHOSPHITES.
Journal of the American Chemical Society.
6275-6276.
1988
-
NUCLEOTIDE CHEMISTRY .22. SYNTHESIS AND CHARACTERIZATION OF DINUCLEOSIDE PHOSPHORODITHIOATES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
2911-2914.
1988
-
SYNTHESIS AND P-DIASTEREOMERIC RESOLUTION OF NUCLEOSIDE 3'-O(S-ALKYL) AND NUCLEOSIDE 3'-O(S-ARYL) METHYLPHOSPHONOTHIOATES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
1227-1230.
1988
-
SYNTHESIS OF DINUCLEOSIDE PHOSPHORODITHIOATES VIA THIOAMIDITES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
5517-5520.
1988
-
MODERN METHODS OF NUCLEIC-ACID SYNTHESIS ON POLYMERIC SUPPORTS.
Reactive and Functional Polymers.
159-174.
1987
- DNA FUNCTIONAL-GROUPS REQUIRED FOR FORMATION OF OPEN COMPLEXES BETWEEN ESCHERICHIA-COLI RNA-POLYMERASE AND THE LAMBDA PR PROMOTER - IDENTIFICATION VIA BASE ANALOG SUBSTITUTIONS. Journal of Biological Chemistry. 892-898. 1987
- ALTERING THE BINDING-SPECIFICITY OF CRO REPRESSOR FOR OPERATOR. Journal of Cellular Biochemistry. 188-188. 1987
- CHEMICAL SYNTHESIS OF DEOXYOLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE METHOD. Methods in Enzymology. 287-313. 1987
-
PHOSPHORAMIDITES AS SYNTHONS FOR POLYNUCLEOTIDE SYNTHESIS.
Phosphorus Sulfur and Silicon and the Related Elements.
549-553.
1987
-
SYNTHESIS OF NUCLEOSIDE METHYLPHOSPHONOTHIOATES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
3205-3208.
1987
-
POLYMER-SUPPORTED RNA-SYNTHESIS AND ITS APPLICATION TO TEST THE NEAREST-NEIGHBOR MODEL FOR DUPLEX STABILITY.
Biochemistry.
7840-7846.
1986
-
IMPROVED FREE-ENERGY PARAMETERS FOR PREDICTIONS OF RNA DUPLEX STABILITY.
Proceedings of the National Academy of Sciences of USA.
9373-9377.
1986
-
NUCLEOTIDE CHEMISTRY .18. CHEMICAL SYNTHESIS OF BRANCHED RNA.
Nucleic Acids Research.
4751-4764.
1986
-
FREE-ENERGY CONTRIBUTIONS OF G.U AND OTHER TERMINAL MISMATCHES TO HELIX STABILITY.
Biochemistry.
3209-3213.
1986
-
STABILITY OF XGCGCP, GCGCYP, AND XGCGCYP HELIXES - AN EMPIRICAL ESTIMATE OF THE ENERGETICS OF HYDROGEN-BONDS IN NUCLEIC-ACIDS.
Biochemistry.
3214-3219.
1986
- PHYSICAL STUDIES OF MUTANT CRO REPRESSOR PROTEINS. The FASEB Journal. 1874-1874. 1986
- STUDIES ON THE CRO REPRESSOR-OPERATOR RECOGNITION PROBLEM. The FASEB Journal. 1829-1829. 1986
-
AMIDINE PROTECTING GROUPS FOR OLIGONUCLEOTIDE SYNTHESIS .16..
Journal of the American Chemical Society.
2040-2048.
1986
- NUCLEIC-ACID SYNTHESIS AND APPLICATIONS TO MOLECULAR-BIOLOGY. Chemica scripta. 25-30. 1986
-
BASE SUBSTITUTION MUTANTS OF THE LAC OPERATOR - INVIVO AND INVITRO AFFINITIES FOR LAC REPRESSOR.
Gene.
123-132.
1986
-
ALTERED CRO REPRESSORS FROM ENGINEERED MUTAGENESIS OF A SYNTHETIC CRO GENE.
Proceedings of the National Academy of Sciences of USA.
1084-1088.
1985
-
GENE SYNTHESIS MACHINES - DNA CHEMISTRY AND ITS USES.
Science.
281-285.
1985
-
LAC UP-PROMOTER MUTANTS WITH INCREASED HOMOLOGY TO THE CONSENSUS PROMOTER SEQUENCE.
Journal of Bacteriology.
1353-1355.
1985
- NEW CHEMICAL METHODS FOR SYNTHESIZING DNA AND RNA. Biochemistry. 3370-3370. 1985
- NEW CHEMICAL METHODS FOR SYNTHESIZING DNA AND RNA. ACS National Meeting Book of Abstracts. 84-BIL. 1985
-
STUDIES ON GENE-CONTROL REGIONS .20. BINDING-STUDIES OF SV40 T-ANTIGEN TO SV40 BINDING SITE-II.
Nucleic Acids Research.
6621-6634.
1985
-
STUDIES ON NUCLEOTIDE CHEMISTRY .15. SYNTHESIS OF OLIGODEOXYNUCLEOTIDES USING AMIDINE PROTECTED NUCLEOSIDES.
Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication.
95-105.
1985
-
A microchemical facility for the analysis and synthesis of genes and proteins.
Nature.
105-111.
1984
- BIOCHEMICAL-STUDIES USING SYNTHETIC DNA. ACS National Meeting Book of Abstracts. 103-BIOL. 1984
- BIOCHEMICAL-STUDIES USING SYNTHETIC DNA. Biochemistry. 3365-3365. 1984
-
CONTROL OF ADENOVIRUS E1B MESSENGER-RNA SYNTHESIS BY A SHIFT IN THE ACTIVITIES OF RNA SPLICE SITES.
Molecular and Cellular Biology.
966-972.
1984
-
INSITU ACTIVATION OF BIS-DIALKYLAMINOPHOSPHINES - A NEW METHOD FOR SYNTHESIZING DEOXYOLIGONUCLEOTIDES ON POLYMER SUPPORTS.
Nucleic Acids Research.
4051-4061.
1984
-
ISOLATION AND CHARACTERIZATION OF A CDNA CLONE FOR BOVINE CYTOCHROME-C OXIDASE SUBUNIT-IV.
Proceedings of the National Academy of Sciences of USA.
6295-6299.
1984
-
MUTANTS OF THE LAC PROMOTER WITH LARGE INSERTIONS AND DELETIONS BETWEEN THE CAP BINDING-SITE AND THE -35 REGION.
Gene.
263-267.
1984
-
NUCLEOTIDE CHEMISTRY .8. SYNTHESIS OF OLIGODEOXYNUCLEOTIDES AND OLIGODEOXYNUCLEOTIDE ANALOGS USING PHOSPHORAMIDITE INTERMEDIATES.
Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr.
95-102.
1984
-
OLIGONUCLEOTIDE MUTAGENESIS OF THE LACPUV5 PROMOTER.
Nucleic Acids Research.
4011-4017.
1984
-
STUDIES ON GENE-CONTROL REGIONS .15. INTERACTION OF AD2+D2 PROTEIN AND SIMIAN VIRUS-40 LARGE T-ANTIGEN WITH THE LARGE TUMOR-ANTIGEN BINDING SITE-I.
Biochemistry.
5938-5944.
1984
-
STUDIES ON GENE-CONTROL REGIONS .15. METHYLPHOSPHONATES AS PROBES OF PROTEIN-NUCLEIC ACID INTERACTIONS.
Nucleic Acids Research.
3387-3404.
1984
-
CHEMICAL SYNTHESIS AND BIOCHEMICAL REACTIVITY OF BACTERIOPHAGE-LAMBDA-PR PROMOTER.
Nucleic Acids Research.
773-787.
1983
-
COLOR CODED TRIARYLMETHYL PROTECTING GROUPS USEFUL FOR DEOXYPOLYNUCLEOTIDE SYNTHESIS.
Nucleic Acids Research.
1589-1599.
1983
- Deoxyoligonucleotide synthesis via the phosphoramidite method.. Gene amplification and analysis. 1-26. 1983
-
INHIBITION OF RNA CLEAVAGE BUT NOT POLYADENYLATION BY A POINT MUTATION IN MESSENGER RNA-3' CONSENSUS SEQUENCE AAUAAA.
Nature.
600-605.
1983
-
NUCLEOTIDE CHEMISTRY .10. AN INVESTIGATION OF SEVERAL DEOXYNUCLEOSIDE PHOSPHORAMIDITES USEFUL FOR SYNTHESIZING DEOXYOLIGONUCLEOTIDES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
245-248.
1983
-
NUCLEOTIDE CHEMISTRY .12. N-6 (N-METHYL-2-PYRROLIDINE AMIDINE)DEOXYADENOSINE - A NEW DEOXYNUCLEOSIDE PROTECTING GROUP.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
2953-2956.
1983
- POINT MUTATIONS OF THE ADENOVIRUS MAJOR LATE PROMOTER WITH DIFFERENT TRANSCRIPTIONAL EFFICIENCIES INVITRO. Journal of Biological Chemistry. 8493-8496. 1983
- Synthesis of the nutL DNA segments and analysis of antitermination and termination functions in coliphage lambda. Gene. 343-354. 1982
- A CALORIMETRIC INVESTIGATION OF THE INTERACTION OF THE LAC REPRESSOR WITH INDUCER. Journal of Biological Chemistry. 4826-4829. 1982
- CHEMICAL SYNTHESIS AND BIOLOGICAL STUDIES ON MUTATED GENE-CONTROL REGIONS. Cold Spring Harbor Laboratory: Symposia on Quantitative Biology. 411-418. 1982
-
IAC OPERON OPERATOR DNA - ISOLATION AND TRIMMING FOR NMR-SPECTROSCOPY.
Analytical Biochemistry.
52-58.
1982
-
METAL-IONS AS SELECTIVE TRIGGERS FOR REMOVING OLIGODEOXYNUCLEOTIDE PHOSPHOTRIESTER PROTECTING GROUPS.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
275-278.
1982
-
RESOLVING THE FUNCTIONS OF OVERLAPPING VIRAL GENES BY SITE-SPECIFIC MUTAGENESIS AT A MESSENGER-RNA SPLICE SITE.
Nature.
380-384.
1982
- THE ROLE OF SYNTHETIC DNA IN RECOMBINANT DNA RESEARCH. DNA and Cell Biology. 166-167. 1982
-
DEOXYNUCLEOSIDE PHOSPHORAMIDITES - A NEW CLASS OF KEY INTERMEDIATES FOR DEOXYPOLYNUCLEOTIDE SYNTHESIS.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
1859-1862.
1981
-
NUCLEOTIDE CHEMISTRY .4. SYNTHESIS OF DEOXYOLIGONUCLEOTIDES ON A POLYMER SUPPORT.
Journal of the American Chemical Society.
3185-3191.
1981
- Sequencing and Synthesis of Nucleic Acids. 299-299. 1981
-
DECIPHERING THE PROTEIN-DNA RECOGNITION CODE.
Accounts of Chemical Research.
155-160.
1980
-
NUCLEOTIDE CHEMISTRY .1. SYNTHESIS OF OLIGODEOXYPYRIMIDINES ON A POLYMER SUPPORT.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
719-722.
1980
-
NUCLEOTIDE CHEMISTRY .2. THE USE OF ZINC BROMIDE FOR REMOVAL OF DIMETHOXYTRITYL ETHERS FROM DEOXYNUCLEOSIDES.
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry.
3243-3246.
1980
- PROGRESS ON CHARACTERIZING THE T-ANTIGEN-SV40 DNA INTERACTION. European Journal of Cell Biology. 84-84. 1980
- Studies in Nucleotide Chemistry III. New Chemical Methods for Synthesizing Polynucleotides. 215-223. 1980
- HOW LAC REPRESSOR RECOGNIZES LAC OPERATOR. The FASEB Journal. 298-298. 1979
-
STUDIES ON GENE-CONTROL REGIONS .10. EFFECT OF SPECIFIC ADENINE-THYMINE TRANSVERSIONS ON THE LAC REPRESSOR-LAC OPERATOR INTERACTION.
Nucleic Acids Research.
2583-2599.
1979
-
STUDIES ON GENE-CONTROL REGIONS .12. FUNCTIONAL-SIGNIFICANCE OF A LAC OPERATOR CONSTITUTIVE MUTATION.
Nucleic Acids Research.
401-416.
1979
-
STUDIES ON GENE-CONTROL REGIONS .9. EFFECT OF HYPOXANTHINE-SUBSTITUTED LAC OPERATORS ON THE LAC OPERATOR LAC REPRESSOR INTERACTION.
Journal of Molecular Biology.
117-135.
1979
-
CLONING OF CHEMICALLY SYNTHESIZED LACTOSE OPERATORS .2. ECORI-LINKERED OPERATORS.
Gene.
211-232.
1978
-
HOW LAC REPRESSOR RECOGNIZES LAC OPERATOR.
Proceedings of the National Academy of Sciences of USA.
3578-3582.
1978
-
STUDIES ON GENE CONTROL REGIONS .7. EFFECT OF 5-BROMOURACIL-SUBSTITUTED LAC OPERATORS ON LAC OPERATOR LAC REPRESSOR INTERACTION.
Journal of Molecular Biology.
661-687.
1978
-
BINDING OF SYNTHETIC LACTOSE OPERATOR DNAS TO LACTOSE REPRESSORS.
Proceedings of the National Academy of Sciences of USA.
3292-3296.
1977
-
CLONING OF CHEMICALLY SYNTHESIZED LACTOSE OPERATORS.
Gene.
305-321.
1977
-
STUDIES ON GENE CONTROL REGIONS .1. CHEMICAL SYNTHESIS OF LACTOSE OPERATOR DEOXYRIBONUCLEIC-ACID SEGMENTS.
Biochemistry.
1765-1772.
1977
-
STUDIES ON GENE CONTROL REGIONS .2. ENZYMATIC JOINING OF CHEMICALLY SYNTHESIZED LACTOSE OPERATOR DEOXYRIBONUCLEIC-ACID SEGMENTS.
Biochemistry.
1772-1780.
1977
-
STUDIES ON GENE CONTROL REGIONS .3. BINDING OF SYNTHETIC AND MODIFIED SYNTHETIC LAC OPERATOR DNAS TO LACTOSE REPRESSOR.
Nucleic Acids Research.
723-728.
1977
-
STUDIES ON GENE CONTROL REGIONS .6. 5-METHYL OF THYMINE, A LAC REPRESSOR RECOGNITION SITE.
Nucleic Acids Research.
3039-3054.
1977
-
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A LAMBDA-PSEUDO OPERATOR.
Biochemistry.
4209-4217.
1977
- Total Synthesis of the Structural Gene for the Precursor of a Tyrosine Suppressor Transfer RNA from Escherichia coli 1. General Introduction. Journal of Biological Chemistry. 565-570. 1976
- Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 10. Enzymatic joining of chemically synthesized segments to form the DNA duplex corresponding to the nucleotide sequence 86-126. Journal of Biological Chemistry. 658-666. 1976
- Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 11. Enzymatic joining to form the total DNA duplex. Journal of Biological Chemistry. 1976
- Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 2. Chemical synthesis of the deoxypolynucleotide segments corresponding to the nucleotide sequence 1-31. Journal of Molecular Biology. 571-586. 1976
- Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 3. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence 27-51. Journal of Biological Chemistry. 587-598. 1976
- Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 4. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence 47-78. Journal of Biological Chemistry. 599-608. 1976
- Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 5. Synthesis of the deoxyribopolynucleotide segments representing the nucleotide sequence 71-103. Journal of Biological Chemistry. 609-623. 1976
- Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 6. Synthesis of the deoxyribopolynucleotide segments corresponding to the nucleotide sequence 100-126. Journal of Biological Chemistry. 624-633. 1976
-
Optimal strategies for the chemical and enzymic synthesis of bihelical deoxyribonucleic acids.
Journal of the American Chemical Society.
875-884.
1975
- SYNTHESIS OF LACTOSE OPERATOR DNA. The FASEB Journal. 554-554. 1975
-
CIII. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast.
Journal of Molecular Biology.
209-217.
1972
-
CIV. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Chemical synthesis of an icosadeoxynucleotide corresponding to the nucleotide sequence 21 to 40.
Journal of Molecular Biology.
219-249.
1972
-
CX. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Synthesis of three decadeoxynucleotides corresponding to the nucleotide sequence 51 to 70.
Journal of Molecular Biology.
375-405.
1972
-
CXI. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Synthesis of a dodecadeoxynucleotide and a heptadeoxynucleotide corresponding to the nucleotide sequence 66 to 77.
Journal of Molecular Biology.
407-426.
1972
-
CXIV. Total synthesis of the structural gene for an alanine transfer RNA from yeast. Enzymic joining of the chemically synthesized segments to form the DNA duplex corresponding to nucleotide sequence 46 to 77.
Journal of Molecular Biology.
457-474.
1972
- CXVII. Hybridization of polydeoxynucleotides with tyrosine transfer RNA sequences to the r-strand of φ80psu^+III DNA. Journal of Molecular Biology. 503-522. 1972
-
Total Synthesis of the Gene for an Alanine Transfer Ribonucleic Acid from Yeast .
Nature.
27-34.
1970
- Progress in the Total Synthesis of the Gene for Alanine tRNA 1968
-
Oligonucleotide syntheses utilizing .beta.-benzoylpropionyl, a blocking group with a trigger for selective cleavage.
Journal of the American Chemical Society.
7146-7147.
1967
-
Reactions of Nucleosides on Polymer Supports. Synthesis of Thymidylylthymidylylthymidine*.
Biochemistry.
1379-1388.
1967
-
Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-in-Sarcoma Amyotrophic Lateral Sclerosis..
International Journal of Molecular Sciences.
2024
Background
education and training
- Ph.D., Northwestern University 1968
- B.S., Iowa State University 1962
awards and honors
International Activities
geographic focus
- China Country
- Czech Republic Country
- France Country
- Japan Country
- Russian Federation Country
- United Kingdom Country