Metabolism - Enzyme Activation PubMed MeSh Term

Overview

subject area of

• Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1  Journal Article
• TERT promoter mutations and telomerase reactivation in urothelial cancer  Journal Article
• A Mechanistic Model of the Enzymatic Hydrolysis of Cellulose  Journal Article
• A Mediator of Rho-dependent Invasion Moonlights as a Methionine Salvage Enzyme  Journal Article
• A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation  Journal Article
• A dual parameter FRET probe for measuring PKC and PKA activity in living cells  Journal Article
• A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras  Journal Article
• A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity  Journal Article
• Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2  Journal Article
• Activation of FAK and Src are receptor-proximal events required for netrin signaling  Journal Article
• Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy  Journal Article
• Activation of the MKK/ERK pathway during somatic cell mitosis: Direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen  Journal Article
• Adaptation mechanism of the aspartate receptor: Electrostatics of the adaptation subdomain play a key role in modulating kinase activity  Journal Article
• Akt and MAPK signaling mediate pregnancy-induced cardiac adaptation  Journal Article
• Analysis of MAP Kinases by Hydrogen Exchange Mass Spectrometry  Journal Article
• Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step  Journal Article
• Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: Primase and the family X polymerases share significant sequence homology  Journal Article
• Biochemical and physicochemical properties of phosphorodithioate DNA  Journal Article
• Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis  Journal Article
• CALF THYMUS DNA-POLYMERASE ALPHA-PRIMASE - COMMUNICATION AND PRIMER-TEMPLATE MOVEMENT BETWEEN THE 2 ACTIVE-SITES  Journal Article
• CDK8 is a stimulus-specific positive coregulator of p53 target genes  Journal Article
• CYTOSOLIC PHOSPHOLIPASE-C ACTIVITY .1. EVIDENCE FOR COUPLING WITH CYTOSOLIC GUANINE-NUCLEOTIDE-BINDING PROTEIN, GI-ALPHA  Journal Article
• Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization  Journal Article
• Cellular Abundance of Mps1 and the Role of Its Carboxyl Terminal Tail in Substrate Recruitment  Journal Article
• Chloroplast thylakoid structure in evergreen leaves employing strong thermal energy dissipation  Journal Article
• Cloning and biochemical characterization of Bacillus subtilis YxiN, a DEAD protein specifically activated by 23S rRNA: delineation of a novel sub-family of bacterial DEAD proteins  Journal Article
• Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching  Journal Article
• Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations  Journal Article
• Coordination of Satellite Cell Activation and Self-Renewal by Par-Complex-Dependent Asymmetric Activation of p38α/β MAPK  Journal Article
• Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins  Journal Article
• Crystal structure of HsIUV complexed with a vinyl sulfone inhibitor: Corroboration of a proposed mechanism of allosteric activation of HsIV by HsIU  Journal Article
• DETERMINATION OF V-MOS-CATALYZED PHOSPHORYLATION SITES AND AUTOPHOSPHORYLATION SITES ON MAP KINASE KINASE BY ESI/MS  Journal Article
• Detection of a conserved alpha-helix in the kinase-docking region of the aspartate receptor by cysteine and disulfide scanning  Journal Article
• Deuterium exchange mass spectrometry as a probe of protein kinase activation. Analysis of wild-type and constitutively active mutants of MAP kinase kinase-1  Journal Article
• Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling  Journal Article
• Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis  Journal Article
• Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry  Journal Article
• Does protein structure influence trypsin miscleavage?  Journal Article
• ERK1/2 activation is a therapeutic target in age-related macular degeneration  Journal Article
• ERK1/2 is required for myoblast proliferation but is dispensable for muscle gene expression and cell fusion  Journal Article
• Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723  Journal Article
• Exercise Protects Against Myocardial Ischemia-Reperfusion Injury via Stimulation of β₃-Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols  Journal Article
• Extracellular signal-regulated kinase activates topoisomerase IIα through a mechanism independent of phosphorylation  Journal Article
• FIBROBLAST GROWTH-FACTOR TREATMENT OF SWISS 3T3 CELLS ACTIVATES A SUBUNIT S6 KINASE THAT PHOSPHORYLATES A SYNTHETIC PEPTIDE SUBSTRATE  Journal Article
• Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1)  Journal Article
• Forward and reverse motion of single RecBCD molecules on DNA  Journal Article
• Functional interaction between telomere protein TPP1 and telomerase  Journal Article
• G alpha 12 and G alpha 13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells  Journal Article
• HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-1 (nNOS)  Journal Article
• Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32.  Journal Article
• High glucose derived endothelial microparticles increase active caspase-3 and reduce microRNA-Let-7a expression in endothelial cells  Journal Article
• Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf^V600E kinase  Journal Article
• Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells  Journal Article
• Human DNA primase: Anion inhibition, manganese stimulation, and their effects on in vitro start-site selection  Journal Article
• Human telomerase: biogenesis, trafficking, recruitment, and activation  Journal Article
• Hydrogen exchange solvent protection by an ATP analogue reveals conformational changes in ERK2 upon activation  Journal Article
• Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38 alpha MAP kinase  Journal Article
• INHIBITION OF A SIGNALING PATHWAY IN CARDIAC-MUSCLE-CELLS BY ACTIVE MITOGEN-ACTIVATED PROTEIN-KINASE KINASE  Journal Article
• Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor  Journal Article
• Identification of G2/M targets for the MAP kinase pathway by functional proteomics  Journal Article
• Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry  Journal Article
• Incorporating expression data in metabolic modeling: A case study of lactate dehydrogenase  Journal Article
• Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts  Journal Article
• Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3  Journal Article
• Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis  Journal Article
• Interdependent domains controlling the enzymatic activity of mitogen-activated protein kinase kinase 1  Journal Article
• Intermolecular tuning of calmodulin by target peptides and proteins: Differential effects on Ca2+ binding and implications for kinase activation  Journal Article
• Interventions to Slow Aging in Humans: Are We Ready?  Journal Article
• Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans  Journal Article
• Involvement of spinal cord nuclear factor κB activation in rat models of proinflammatory cytokine-mediated pain facilitation  Journal Article
• Ionizing radiation induces caspase-dependent but Chk2-and p53-independent cell death in Drosophila melanogaster  Journal Article
• Kinase Activation by Small Conformational Changes  Journal Article
• Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)  Journal Article
• Lipase Activation and Stabilization in Room-Temperature Ionic Liquids  Journal Article
• Lipase Activation and Stabilization in Room-Temperature Ionic Liquids  Chapter
• MITOGEN-ACTIVATED PROTEIN (MAP) KINASE PHOSPHORYLATION OF MAP KINASE KINASE - DETERMINATION OF PHOSPHORYLATION SITES BY MASS-SPECTROMETRY AND SITE-DIRECTED MUTAGENESIS  Journal Article
• MOS STIMULATES MAP KINASE IN XENOPUS OOCYTES AND ACTIVATES A MAP KINASE KINASE INVITRO  Journal Article
• MYOSIN LIGHT CHAIN KINASES AND MYOSIN PHOSPHORYLATION IN SKELETAL-MUSCLE  Journal Article
• Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying  Journal Article
• Mapping out regions on the surface of the aspartate receptor that are essential for kinase activation  Journal Article
• Material-based regulation of the myofibroblast phenotype  Journal Article
• Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.  Journal Article
• Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase  Journal Article
• Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death  Journal Article
• Molecular mechanism of transmembrane signaling by the aspartate receptor: A model  Journal Article
• Monitoring post-translational modification of proteins with allosteric ribozymes  Journal Article
• Mps1 activation loop autophosphorylation enhances kinase activity  Journal Article
• Multiple folding pathways for the P4-P6 RNA domain  Journal Article
• Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis  Journal Article
• Non-oxime pyrazole based inhibitors of B-Raf kinase  Journal Article
• Optically Diffracting Hydrogels for Screening Kinase Activity in Vitro and in Cell Lysate: Impact of Material and Solution Properties  Journal Article
• PHOSPHORYLATED IMMUNORECEPTOR SIGNALING MOTIFS (ITAMS) EXHIBIT UNIQUE ABILITIES TO BIND AND ACTIVATE LYN AND SYK TYROSINE KINASES  Journal Article
• PREPARATION OF FLUORESCENT LABELED CALMODULINS  Journal Article
• Pharmacologic inhibitors of MKK1 and MKK2  Journal Article
• Phosphorylation releases constraints to domain motion in ERK2  Journal Article
• Phosphorylation-dependent changes in structure and dynamics in ERK2 detected by SDSL and EPR  Journal Article
• Protein activation of a ribozyme: the role of bacterial RNase P protein  Journal Article
• Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor  Journal Article
• RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP  Journal Article
• Redox Regulation of SH2-Domain-Containing Protein Tyrosine Phosphatases by Two Backdoor Cysteines  Journal Article
• Regulation of CED-3 caspase localization and activation by C-elegans nuclear-membrane protein NPP-14  Journal Article
• Regulation of histone methylation by automethylation of PRC2  Journal Article
• Regulation of mitochondrial membrane premeabilization by BCL-2 family proteins and caspases  Journal Article
• Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA  Journal Article
• SYNTHESIS AND BIOCHEMICAL-STUDIES OF DITHIOATE DNA  Journal Article
• Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription  Journal Article
• Single-Molecule Studies Reveal a Hidden Key Step in the Activation Mechanism of Membrane-Bound Protein Kinase C-α  Journal Article
• Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP₃ Signaling  Journal Article
• Structural and Biophysical Studies of Human PARP-1 in Complex with Damaged DNA  Journal Article
• Structural and mechanistic insights into Mps1 kinase activation  Journal Article
• Structure and mechanism of the RNA polymerase II transcription machinery  Journal Article
• Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans  Journal Article
• TRANSFORMATION OF MAMMALIAN-CELLS BY CONSTITUTIVELY ACTIVE MAP KINASE KINASE  Journal Article
• Tetrahymena telomerase is active as a monomer  Journal Article
• The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator  Journal Article
• The PH Domain of Phosphoinositide-Dependent Kinase-1 Exhibits a Novel, Phospho-Regulated Monomer-Dimer Equilibrium with Important Implications for Kinase Domain Activation: Single-Molecule and Ensemble Studies  Journal Article
• The cell cycle program in germ cells of the Drosophila embryo.  Journal Article
• The cytoplasmic amino-terminus of the Latent Membrane Protein-1 of Epstein-Barr Virus: relationship between transmembrane orientation and effector functions of the carboxy-terminus and transmembrane domain  Journal Article
• The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity  Journal Article
• The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation  Journal Article
• The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf  Journal Article
• The p38α/β MAPK functions as a molecular switch to activate the quiescent satellite cell  Journal Article
• The role of Akt/GSK-3 beta signaling in familial hypertrophic cardiomyopathy  Journal Article
• Use of salt hydrate pairs to control water activity for enzyme catalysis in ionic liquids  Journal Article
• X-ray crystallography of large RNAs: Heavy-atom derivatives by RNA engineering  Journal Article
• c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro  Journal Article
• dsRNA-induced condensation of antiviral proteins modulates PKR activity  Journal Article

broader concept

• Metabolism  PubMed MeSh Term