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Han, Min Distinguished Professor

Positions

Research Areas research areas

Research

research overview

  • Han lab has engaged in dynamic research programs addressing important biological problems related to human diseases, primarily using C. elegans and mouse. The lab always aims for important questions in relatively unexplored areas and encourages researchers to generate their own ideas. In the early 90s, the lab focused on identifying key regulators of the RTK-RAS-MAP kinase signaling, and then extended efforts to tackling genetic redundancy. In the late 90s, some researchers moved to study cellular/morphogenesis events during development, including discovering the SUN-KASH NE complexes and their functions. The lab has also made breakthrough advances in studying the functions of miRNAs and non-canonic caspase activities using systematic methods. In recent years, the lab discovered four novel nutrient sensing mechanisms that regulate development, reproductivity and behavior in response to changes in fatty acids and nucleotide variants. We are also exploring nutrients from gut microbes.

keywords

  • Functions of lipids, lipid metabolism and small RNAs in animal development and behaviors under various physiological conditions, Stress responses, starvation responses, Nucleotide metabolism, C elegans and mouse genetics, nuclear envelope complexes, nutrient response, metabolism, environmental sex determination, nucleotide sensing, non-canonic function of caspases, impact of gut of microbes on animal physiology, iron uptake

Publications

selected publications

Teaching

courses taught

  • MCDB 4425 - Topics in Membrane Biology: Cell Biology, Physiology and Disease
    Primary Instructor - Spring 2019
    Students will apply their knowledge of basic biology to exploring several of the most exciting topics in biomedicine including protein folding and stress responses, nutrient sensing and balance and signal transduction across membranes. Emphasis will be placed upon human physiology and associated human diseases including Alzheimer's disease, diabetes and cardiovascular disease. Fulfills MCDB scientific reasoning requirement. Recommended prerequisites: MCDB 3135 and MCDB 3145 (minimum grade C-) or instructor consent required. Same as MCDB 5425.
  • MCDB 4980 - Honors Research
    Primary Instructor - Fall 2019
    Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Fall 2019
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
  • MCDB 5425 - Topics in Membrane Biology: Cell Biology, Physiology and Disease
    Primary Instructor - Spring 2019
    Students will apply their knowledge of basic biology to exploring several of the most exciting topics in biomedicine including protein folding and stress responses, nutrient sensing and balance and signal transduction across membranes. Emphasis will be placed upon human physiology and associated human diseases including Alzheimer's disease, diabetes and cardiovascular disease. Same as MCDB 4425.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles