research overview
- Dr. Randolph's research is focused on the stabilization and delivery of protein-based therapeutics and vaccines.
- Contact Info
Randolph, Theodore W
Positions
- Endowed/Named Professor, College of Engineering and Applied Science
- Professor, Chemical and Biological Engineering
Research Areas
Research
keywords
- protein stabilization, vaccine development, drug delivery
Publications
selected publications
-
chapter
-
Formulation Approaches and Strategies for Vaccines and Adjuvants.
AAPS Advances in the Pharmaceutical Sciences Series.
145-164.
2013
- Physical Instability of Peptides and Proteins. 107-129. 2013
- THERMODYNAMICS OF THE PHYSICAL STABILITY OF PROTEIN SOLUTIONS. 315-353. 2013
- Physical Damage to Proteins During Freezing, Drying, and Reconstitution 2004
- Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice 2002
- PRESSURE CONTROL OF REACTIONS IN SUPERCRITICAL FLUIDS - THERMODYNAMICS AND KINETICS. Progress in Biotechnology -Amsterdam-. 93-100. 1992
-
Formulation Approaches and Strategies for Vaccines and Adjuvants.
AAPS Advances in the Pharmaceutical Sciences Series.
145-164.
2013
-
conference proceeding
- IMMUNOGENICITY AND EFFICACY OF RECOMBINANT SUBUNIT FILOVIRUS VACCINES IN NON-HUMAN PRIMATES AND DEVELOPMENT OF THERMOSTABLE FORMULATIONS. American Journal of Tropical Medicine and Hygiene. 262-262. 2019
-
journal article
-
Lipid-free, thermostable mRNA vaccines prepared using atomic layer deposition..
Journal of Pharmaceutical Sciences.
104066.
2026
-
Broad anti-sarbecovirus responses elicited by a single administration of mosaic-8 RBD-nanoparticle vaccine prepared using atomic layer deposition.
iScience.
2025
-
Superior immune responses from thermostable, single-administration rabies vaccines prepared using atomic layer deposition.
Journal of Pharmaceutical Sciences.
2025
-
Unsupervised Machine Learning-Based Process Analytical Tools for Near Real-Time Cell Morphology Analysis During CAR-T Cell Manufacturing.
Biotechnology and Bioengineering.
2377-2388.
2025
-
Representative training data sets are critical for accurate machine-learning classification of microscopy images of particles formed by lipase-catalyzed polysorbate hydrolysis.
Journal of Pharmaceutical Sciences.
1254-1263.
2025
-
Formulation of three tailed bacteriophages by spray-drying and atomic layer deposition for thermal stability and controlled release.
Journal of Pharmaceutical Sciences.
3238-3245.
2024
-
Stabilization of an Infectious Enveloped Virus by Spray-Drying and Lyophilization.
Journal of Pharmaceutical Sciences.
2072-2080.
2024
-
Stain-Free Approach to Determine and Monitor Cell Heath Using Supervised and Unsupervised Image-Based Deep Learning.
Journal of Pharmaceutical Sciences.
2114-2127.
2024
-
Features in Backgrounds of Microscopy Images Introduce Biases in Machine Learning Analyses.
Journal of Pharmaceutical Sciences.
1177-1189.
2024
-
Supervised and unsupervised machine learning approaches for monitoring subvisible particles within an aluminum-salt adjuanted vaccine formulation.
Biotechnology and Bioengineering.
1626-1641.
2024
-
Effect of mechanical stresses on viral capsid disruption during droplet formation and drying.
Colloids and Surfaces B: Biointerfaces.
2024
-
Interfacial Adsorption Controls Particle Formation in Antibody Formulations Subjected to Extensional Flows and Hydrodynamic Shear.
Journal of Pharmaceutical Sciences.
2766-2777.
2023
-
A Single Dose, Thermostable, Trivalent Human Papillomavirus Vaccine Formulated Using Atomic Layer Deposition.
Journal of Pharmaceutical Sciences.
2223-2229.
2023
-
Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates.
Journal of Pharmaceutical Sciences.
3424-3434.
2022
-
Machine learning approaches to root cause analysis, characterization, and monitoring of subvisible particles in monoclonal antibody formulations.
Biotechnology and Bioengineering.
3596-3611.
2022
-
Machine Learning Analysis Provides Insight into Mechanisms of Protein Particle Formation Inside Containers During Mechanical Agitation.
Journal of Pharmaceutical Sciences.
2730-2744.
2022
-
Atomic-Layer Deposition Processes Applied to Phage lambda and a Phage-like Particle Platform Yield Thermostable, Single-Shot Vaccines.
Journal of Pharmaceutical Sciences.
1354-1362.
2022
-
An Interlaboratory Comparison on the Characterization of a Sub-micrometer Polydisperse Particle Dispersion.
Journal of Pharmaceutical Sciences.
699-709.
2022
-
Testing Precision Limits of Neural Network-Based Quality Control Metrics in High-Throughput Digital Microscopy.
Pharmaceutical Research.
263-279.
2022
-
Thermostability of a trivalent, capsomere-based vaccine for human papillomavirus infection.
European journal of pharmaceutics and biopharmaceutics.
131-138.
2021
-
Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation.
ACS Applied Bio Materials.
6946-6953.
2021
-
Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant.
Vaccine.
5650-5657.
2021
-
Insulin Fibril Formation Caused by Mechanical Shock and Cavitation.
Journal of Physical Chemistry B.
8021-8027.
2021
-
Machine learning and accelerated stress approaches to differentiate potential causes of aggregation in polyclonal antibody formulations during shipping.
Journal of Pharmaceutical Sciences.
2743-2752.
2021
-
Stability of lyophilized and spray dried vaccine formulations.
Advanced Drug Delivery Reviews.
50-61.
2021
-
Preservation of Quaternary Structure in Thermostable, Lyophilized Filovirus Glycoprotein Vaccines: A Search for Stability-Indicating Assays.
Journal of Pharmaceutical Sciences.
3716-3727.
2020
-
Machine learning and statistical analyses for extracting and characterizing "fingerprints" of antibody aggregation at container interfaces from flow microscopy images.
Biotechnology and Bioengineering.
3322-3335.
2020
-
The Effect of Container Surface Passivation on Aggregation of Intravenous Immunoglobulin Induced by Mechanical Shock.
Biotechnology Journal.
2020
-
Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology.
npj Vaccines.
2020
-
Aggregation and Particle Formation During Pumping of an Antibody Formulation Are Controlled by Electrostatic Interactions Between Pump Surfaces and Protein Molecules.
Journal of Pharmaceutical Sciences.
1473-1482.
2020
-
Container Surfaces Control Initiation of Cavitation and Resulting Particle Formation in Protein Formulations After Application of Mechanical Shock.
Journal of Pharmaceutical Sciences.
1270-1280.
2020
-
DEHP Nanodroplets Leached From Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum.
Journal of Pharmaceutical Sciences.
429-442.
2020
-
Nanobubbles in Reconstituted Lyophilized Formulations: Interaction With Proteins and Mechanism of Formation.
Journal of Pharmaceutical Sciences.
284-292.
2020
-
Subvisible Particles in IVIg Formulations Activate Complement in Human Serum.
Journal of Pharmaceutical Sciences.
558-565.
2020
-
Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions.
Journal of Pharmaceutical Sciences.
1973-1983.
2019
-
Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations.
Journal of Pharmaceutical Sciences.
1110-1116.
2019
-
Thermostable Ebola virus vaccine formulations lyophilized in the presence of aluminum hydroxide.
European journal of pharmaceutics and biopharmaceutics.
213-220.
2019
-
Steric Repulsion Forces Contributed by PEGylation of Interleukin-1 Receptor Antagonist Reduce Gelation and Aggregation at the Silicone Oil-Water Interface.
Journal of Pharmaceutical Sciences.
162-172.
2019
-
Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues.
Journal of Pharmaceutical Sciences.
2013-2019.
2018
-
Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations.
Journal of Pharmaceutical Sciences.
2070-2078.
2018
-
Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses.
Journal of Pharmaceutical Sciences.
1852-1857.
2018
-
Protein-protein interactions controlling interfacial aggregation of rhIL-1ra are not described by simple colloid models.
Protein Science.
1191-1204.
2018
-
Flow Microscopy Imaging Is Sensitive to Characteristics of Subvisible Particles in Peginesatide Formulations Associated With Severe Adverse Reactions.
Journal of Pharmaceutical Sciences.
1313-1321.
2018
-
Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations.
Journal of Pharmaceutical Sciences.
999-1008.
2018
-
Response to Comment to the Editor.
Biophysical Journal.
755-756.
2017
-
Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models.
Journal of Pharmaceutical Sciences.
1519-1527.
2017
-
Microflow Imaging Analyses Reflect Mechanisms of Aggregate Formation: Comparing Protein Particle Data Sets Using the Kullback-Leibler Divergence.
Journal of Pharmaceutical Sciences.
1239-1248.
2017
-
Aggregation of amphipathic peptides at an aqueous-organic interface using coarse-grained simulations.
Molecular Simulation.
1448-1458.
2017
-
Challenges in Predicting Protein-Protein Interactions from Measurements of Molecular Diffusivity.
Biophysical Journal.
1831-1842.
2016
-
Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions.
Journal of Pharmaceutical Sciences.
3057-3063.
2016
-
Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces.
Journal of Pharmaceutical Sciences.
2338-2348.
2016
-
Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20.
Journal of Pharmaceutical Sciences.
2302-2309.
2016
-
Formation of Stable Nanobubbles on Reconstituting Lyophilized Formulations Containing Trehalose.
Journal of Pharmaceutical Sciences.
2249-2253.
2016
-
Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges.
Journal of Pharmaceutical Sciences.
1567-1575.
2016
-
Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice.
Journal of Pharmaceutical Sciences.
1623-1632.
2016
-
Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes.
Journal of Pharmaceutical Sciences.
4056-4064.
2015
-
The Role of Protein Excipient in Driving Antibody Responses to Erythropoietin.
Journal of Pharmaceutical Sciences.
4041-4055.
2015
-
In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations.
Journal of Pharmaceutical Sciences.
3681-3690.
2015
-
Development of a highly thermostable, adjuvanted human papillomavirus vaccine.
European journal of pharmaceutics and biopharmaceutics.
220-228.
2015
-
Electrostatic Interactions Influence Protein Adsorption (but Not Desorption) at the Silica-Aqueous Interface.
Journal of Physical Chemistry Letters.
2583-2587.
2015
-
Molecular Trajectories Provide Signatures of Protein Clustering and Crowding at the Oil/Water Interface.
Langmuir.
5882-5890.
2015
-
Dose Levels in Particulate-Containing Formulations Impact Anti-drug Antibody Responses to Murine Monoclonal Antibody in Mice.
Journal of Pharmaceutical Sciences.
1610-1621.
2015
-
Effect of the Siliconization Method on Particle Generation in a Monoclonal Antibody Formulation in Pre-filled Syringes.
Journal of Pharmaceutical Sciences.
1601-1609.
2015
-
Gelation of a Monoclonal Antibody at the Silicone Oil-Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation.
Journal of Pharmaceutical Sciences.
1282-1290.
2015
-
Do Not Drop: Mechanical Shock in Vials Causes Cavitation, Protein Aggregation, and Particle Formation.
Journal of Pharmaceutical Sciences.
602-611.
2015
-
Glassy-State Stabilization of a Dominant Negative Inhibitor Anthrax Vaccine Containing Aluminum Hydroxide and Glycopyranoside Lipid A Adjuvants.
Journal of Pharmaceutical Sciences.
627-639.
2015
-
Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice.
Pharmaceutical Research.
430-444.
2015
-
Storage stability of keratinocyte growth factor-2 in lyophilized formulations: Effects of formulation physical properties and protein fraction at the solid-air interface.
European journal of pharmaceutics and biopharmaceutics.
332-341.
2014
-
The Effect of Protein PEGylation on Physical Stability in Liquid Formulation.
Journal of Pharmaceutical Sciences.
3043-3054.
2014
-
Effects of Phenol and meta-Cresol Depletion on Insulin Analog Stability at Physiological Temperature.
Journal of Pharmaceutical Sciences.
2255-2267.
2014
-
Freezing-Induced Perturbation of Tertiary Structure of a Monoclonal Antibody.
Journal of Pharmaceutical Sciences.
1979-1986.
2014
-
UV photodegradation of murine growth hormone: Chemical analysis and immunogenicity consequences.
European journal of pharmaceutics and biopharmaceutics.
395-402.
2014
-
Protein Aggregation and Particle Formation in Prefilled Glass Syringes.
Journal of Pharmaceutical Sciences.
1601-1612.
2014
-
Partial Unfolding of a Monoclonal Antibody: Role of a Single Domain in Driving Protein Aggregation.
Biochemistry.
3367-3377.
2014
-
Protein Quantity on the Air-Solid Interface Determines Degradation Rates of Human Growth Hormone in Lyophilized Samples.
Journal of Pharmaceutical Sciences.
1356-1366.
2014
-
Investigations into the Fouling Mechanism of Parvovirus Filters During Filtration of Freeze-Thawed mAb Drug Substance Solutions.
Journal of Pharmaceutical Sciences.
890-899.
2014
-
Albinterferon alpha(2b) Adsorption to Silicone Oil-Water Interfaces: Effects on Protein Conformation, Aggregation, and Subvisible Particle Formation.
Journal of Pharmaceutical Sciences.
427-436.
2014
-
Antibody Responses in Mice to Particles Formed from Adsorption of a Murine Monoclonal Antibody onto Glass Microparticles.
Journal of Pharmaceutical Sciences.
78-89.
2014
-
Preformulation Study of Highly Purified Inactivated Polio Vaccine, Serotype 3.
Journal of Pharmaceutical Sciences.
140-151.
2014
-
Recombinant Murine Growth Hormone Particles are More Immunogenic with Intravenous than Subcutaneous Administration.
Journal of Pharmaceutical Sciences.
128-139.
2014
-
Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions.
European journal of pharmaceutics and biopharmaceutics.
177-183.
2013
-
Lyophilization of a triply unsaturated phospholipid: Effects of trace metal contaminants.
European journal of pharmaceutics and biopharmaceutics.
306-313.
2013
-
Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.
European journal of pharmaceutics and biopharmaceutics.
279-286.
2013
-
The effects of excipients on protein aggregation during agitation: An interfacial shear rheology study.
Journal of Pharmaceutical Sciences.
2460-2470.
2013
-
IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: A model for siliconized primary containers.
Journal of Pharmaceutical Sciences.
852-865.
2013
-
Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation.
Journal of Pharmaceutical Sciences.
660-673.
2013
-
Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces.
Journal of Pharmaceutical Sciences.
429-440.
2013
-
Contributions of local mobility and degree of retention of native secondary structure to the stability of recombinant human growth hormone (rhGH) in glassy lyophilized formulations.
Soft Matter.
7855-7865.
2013
-
Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions.
Journal of Pharmaceutical Sciences.
4419-4432.
2012
-
Particles shed from syringe filters and their effects on agitation-induced protein aggregation.
Journal of Pharmaceutical Sciences.
2952-2959.
2012
-
Physical stability of albinterferon-alpha(2b) in aqueous solution: Effects of conformational stability and colloidal stability on aggregation.
Journal of Pharmaceutical Sciences.
2702-2719.
2012
-
Accelerated Stability Studies of Abatacept Formulations: Comparison of Freeze-Thawing- and Agitation-Induced Stresses.
Journal of Pharmaceutical Sciences.
2307-2315.
2012
-
Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate.
Journal of Pharmaceutical Sciences.
2009-2016.
2012
-
Selective domain stabilization as a strategy to reduce fusion protein aggregation.
Journal of Pharmaceutical Sciences.
1400-1409.
2012
-
Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release.
Journal of Pharmaceutical Sciences.
946-954.
2012
-
Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene.
Journal of Pharmaceutical Sciences.
187-199.
2012
-
Production of particles of therapeutic proteins at the air-water interface during compression/dilation cycles.
Soft Matter.
10329-10335.
2012
-
The two faces of His-tag: Immune response versus ease of protein purification.
Biotechnology Journal.
18-19.
2012
-
Glass Particles as an Adjuvant: A Model for Adverse Immunogenicity of Therapeutic Proteins.
Journal of Pharmaceutical Sciences.
4953-4964.
2011
-
Effect of Benzyl Alcohol on Recombinant Human Interleukin-1 Receptor Antagonist Structure and Hydrogen-Deuterium Exchange.
Journal of Pharmaceutical Sciences.
4215-4224.
2011
-
Effects of Surfaces and Leachables on the Stability of Biopharmaceuticals.
Journal of Pharmaceutical Sciences.
4158-4170.
2011
-
Quaternary Conformational Stability: The Effect of Reversible Self-Association on the Fibrillation of Two Insulin Analogs.
Biotechnology and Bioengineering.
2359-2370.
2011
-
Non-oxime pyrazole based inhibitors of B-Raf kinase.
Bioorganic and Medicinal Chemistry Letters.
3488-3492.
2011
-
Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.
ACS Medicinal Chemistry Letters.
342-347.
2011
-
Flow cytometry: A promising technique for the study of silicone oil-induced particulate formation in protein formulations.
Analytical Biochemistry.
191-199.
2011
-
Aggregation of Recombinant Human Botulinum Protein Antigen Serotype C in Varying Solution Conditions: Implications of Conformational Stability for Aggregation Kinetics.
Journal of Pharmaceutical Sciences.
836-848.
2011
-
The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Bioorganic and Medicinal Chemistry Letters.
1248-1252.
2011
-
Subvisible Particle Counting Provides a Sensitive Method of Detecting and Quantifying Aggregation of Monoclonal Antibody Caused by Freeze-Thawing: Insights Into the Roles of Particles in the Protein Aggregation Pathway.
Journal of Pharmaceutical Sciences.
492-503.
2011
-
Adsorption of Monoclonal Antibodies to Glass Microparticles.
Journal of Pharmaceutical Sciences.
123-132.
2011
-
Crystallization of Recombinant Human Growth Hormone at Elevated Pressures: Pressure Effects on PEG-Induced Volume Exclusion Interactions.
Biotechnology and Bioengineering.
663-672.
2010
-
Buffer-Dependent Fragmentation of a Humanized Full-Length Monoclonal Antibody.
Journal of Pharmaceutical Sciences.
2962-2974.
2010
-
Potential Inaccurate Quantitation and Sizing of Protein Aggregates by Size Exclusion Chromatography: Essential Need to Use Orthogonal Methods to Assure the Quality of Therapeutic Protein Products.
Journal of Pharmaceutical Sciences.
2200-2208.
2010
-
Recombinant Murine Growth Hormone from E. coli Inclusion Bodies: Expression, High-Pressure Solubilization and Refolding, and Characterization of Activity and Structure.
Biotechnology Progress.
743-749.
2010
-
Protein Adsorption and Excipient Effects on Kinetic Stability of Silicone Oil Emulsions.
Journal of Pharmaceutical Sciences.
1721-1733.
2010
-
Inhibition of Agitation-Induced Aggregation of an IgG-Antibody by Hydroxypropyl-β-Cyclodextrin.
Journal of Pharmaceutical Sciences.
1193-1206.
2010
-
Aggregation of a Monoclonal Antibody Induced by Adsorption to Stainless Steel.
Biotechnology and Bioengineering.
121-129.
2010
-
Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation.
Journal of Pharmaceutical Sciences.
82-93.
2010
-
Physical Instability of a Therapeutic Fc Fusion Protein: Domain Contributions to Conformational and Colloidal Stability.
Biochemistry.
11724-11736.
2009
-
Evaluation of Chemical Degradation of a Trivalent Recombinant Protein Vaccine Against Botulinum Neurotoxin by LysC Peptide Mapping and MALDI-TOF Mass Spectrometry.
Journal of Pharmaceutical Sciences.
2994-3012.
2009
-
Immunogenicity of Aggregates of Recombinant Human Growth Hormone in Mouse Models.
Journal of Pharmaceutical Sciences.
3247-3264.
2009
-
Mixing Properties of Lyophilized Protein Systems: A Spectroscopic and Calorimetric Study.
Journal of Pharmaceutical Sciences.
2954-2969.
2009
-
Monoclonal Antibody Interactions With Micro- and Nanoparticles: Adsorption, Aggregation, and Accelerated Stress Studies.
Journal of Pharmaceutical Sciences.
3218-3238.
2009
-
Precipitation of a Monoclonal Antibody by Soluble Tungsten.
Journal of Pharmaceutical Sciences.
3290-3301.
2009
-
Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution.
Journal of Pharmaceutical Sciences.
3167-3181.
2009
-
Stability of a Trivalent Recombinant Protein Vaccine Formulation Against Botulinum Neurotoxin During Storage in Aqueous Solution.
Journal of Pharmaceutical Sciences.
2970-2993.
2009
-
Response of a Concentrated Monoclonal Antibody Formulation to High Shear.
Biotechnology and Bioengineering.
936-943.
2009
-
Role of electrostatic repulsion on colloidal stability of Bacillus halmapalus alpha-amylase.
Biochimica et Biophysica Acta - Proteins and Proteomics.
1058-1065.
2009
-
Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality.
Journal of Pharmaceutical Sciences.
1201-1205.
2009
- Aggregation and stability characterization of abatacept (orencia), a therapeutic fusion protein. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 607-607. 2009
-
Refolding of Proteins From Inclusion Bodies Is Favored by a Diminished Hydrophobic Effect at Elevated Pressures.
Biotechnology and Bioengineering.
483-492.
2009
-
Common Excipients Impair Detection of Protein Aggregates during Sedimentation Velocity Analytical Ultracentrifugation.
Journal of Pharmaceutical Sciences.
50-62.
2009
-
IgG Particle Formation during Filling Pump Operation: A Case Study of Heterogeneous Nucleation on Stainless Steel Nanoparticles.
Journal of Pharmaceutical Sciences.
94-104.
2009
-
Influence of Protein Conformation and Adjuvant Aggregation on the Effectiveness of Aluminum Hydroxide Adjuvant in a Model Alkaline Phosphatase Vaccine.
Journal of Pharmaceutical Sciences.
114-121.
2009
-
Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium (vol 377, pg 128, 2008).
Analytical Biochemistry.
349-349.
2008
-
Effect of pH on Stability of Recombinant Botulinum Serotype A Vaccine in Aqueous Solution and During Storage of Freeze-Dried Formulations.
Journal of Pharmaceutical Sciences.
5132-5146.
2008
-
Influence of Particle Size and Antigen Binding on Effectiveness of Aluminum Salt Adjuvants in a Model Lysozyme Vaccine.
Journal of Pharmaceutical Sciences.
5252-5262.
2008
- BIOT 249-Lyophilized, adjuvanted vaccines: Processing effects on particle size, protein stability, protein adsorption and efficacy. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008
- BIOT 29-Opalescence in antibody formulations is a solution critical phenomenon. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008
- BIOT 32-Buffer-dependent fragmentation of a humanized full-length monoclonal antibody. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008
- BIOT 338-High hydrostatic pressures as a tool to recover folded protein from aggregates and inclusion bodies. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008
- BIOT 94-Interactions of an IgG1 with siliconized glass beads. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008
- BIOT 95-The interaction of a monoclonal antibody with stainless steel, cellulose, glass, and tungsten. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008
-
Potent and selective pyrazole-based inhibitors of B-Raf kinase.
Bioorganic and Medicinal Chemistry Letters.
4692-4695.
2008
-
High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization.
Journal of Pharmaceutical Sciences.
3035-3050.
2008
-
High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics.
Journal of Pharmaceutical Sciences.
3005-3021.
2008
-
Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium.
Analytical Biochemistry.
128-133.
2008
-
Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying.
Journal of Pharmaceutical Sciences.
2051-2061.
2008
-
Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing.
Journal of Pharmaceutical Sciences.
1801-1812.
2008
-
Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry.
Journal of Pharmaceutical Sciences.
1013-1024.
2008
-
Specific volume and adiabatic compressibility measurements of native and aggregated recombinant human interleukin-1 receptor antagonist: Density differences enable pressure-modulated refolding.
Biotechnology and Bioengineering.
476-485.
2007
-
Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt Adjuvants.
Journal of Pharmaceutical Sciences.
2375-2389.
2007
- BIOT 10-Aggregation of a monoclonal antibody induced by adsorption to microparticle surfaces. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2007
- BIOT 227-Silicone oil contamination of therapeutic protein formulations: Surfactant and protein effects. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2007
- BIOT 230-Discrepancies in the phase behaviors of therapeutic antibodies. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2007
-
Engineering challenges of protein formulations.
AIChE Journal.
1902-1907.
2007
-
Influence of hydrostatic pressure and cosolutes on RNA tertiary structure.
Journal of the American Chemical Society.
9290-+.
2007
-
Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: Implications of conformational stability on protein oxidation kinetics.
Biochemistry.
6213-6224.
2007
-
Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.
188-198.
2007
-
Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity.
Journal of Pharmaceutical Sciences.
268-279.
2007
-
Sedimentation velocity analytical ultracentrifugation and SEDFIT/c(s): Limits of quantitation for a monoclonal antibody system.
Analytical Biochemistry.
24-30.
2007
-
Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor.
Journal of Pharmaceutical Sciences.
1480-1497.
2006
-
Scale-up criteria for an injector with a confined mixing chamber during precipitation with a compressed-fluid antisolvent.
Journal of Supercritical Fluids.
242-253.
2006
-
Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist.
Biochemistry.
3898-3911.
2006
-
Surfactant-induced unfolding of cellulase: Kinetic studies.
Biotechnology Progress.
225-232.
2006
-
Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure.
Protein Science.
304-313.
2006
-
High-pressure studies on protein aggregates and amyloid fibrils.
Methods in Enzymology.
237-253.
2006
-
Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist.
Journal of Pharmaceutical Sciences.
2735-2748.
2005
-
Supercritical fluid crystallization of griseofulvin: Crystal habit modification with a selective growth inhibitor.
Journal of Pharmaceutical Sciences.
2688-2702.
2005
-
Ca2+-surfactant interactions affect enzyme stability in detergent solutions.
Biotechnology Progress.
1716-1723.
2005
-
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages.
Journal of Controlled Release.
288-299.
2005
-
High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: Thermodynamics, kinetics, and application to accelerated formulation studies.
Protein Science.
2258-2266.
2005
-
Propagation and termination kinetics of cross-linking photopolymerizations studied using electron paramagnetic resonance spectroscopy in conjunction with near IR spectroscopy.
Macromolecules.
6954-6964.
2005
-
Effects of Tween 20® and Tween 80® on the stability of albutropin during agitation.
Journal of Pharmaceutical Sciences.
1368-1381.
2005
- High-Hydrostatic pressure refolding of proteins. Genetic Engineering News. 46-47. 2005
-
Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations.
Journal of Pharmaceutical Sciences.
382-396.
2005
-
Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation.
Journal of Pharmaceutical Sciences.
256-274.
2005
-
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution.
Journal of Pharmaceutical Sciences.
3076-3089.
2004
-
Degradation kinetics of high molecular weight poly (L-lactide) microspheres and release mechanism of lipid:DNA complexes.
Journal of Pharmaceutical Sciences.
2573-2584.
2004
-
High-pressure refolding of bikunin: Efficacy and thermodynamics.
Protein Science.
2639-2650.
2004
-
Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations.
Journal of Pharmaceutical Sciences.
2332-2342.
2004
-
Nucleation and growth rates of poly(L-lactic acid) microparticles during precipitation with a compressed-fluid antisolvent.
Langmuir.
7254-7264.
2004
- Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations. Protein Science. 54-54. 2004
- Reversal of protein aggregation under high hydrostatic pressures.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U214-U214. 2004
-
Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures.
Journal of Pharmaceutical Sciences.
684-696.
2004
-
Protease autolysis in heavy-duty liquid detergent formulations: effects of thermodynamic stabilizers and protease inhibitors.
Enzyme and Microbial Technology.
114-125.
2004
-
Manipulation of particle size distribution of poly(L-lactic acid) nanoparticles with a jet-swirl nozzle during precipitation with a compressed antisolvent.
Journal of Supercritical Fluids.
317-336.
2003
-
In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response.
Journal of Controlled Release.
147-161.
2003
- Effect of calcium-micelle interactions on subtilisin stability in surfactant solutions.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U372-U372. 2003
- High pressure refolding of bikunin protein aggregates - Efficacy and thermodynamics.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U186-U186. 2003
-
Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation.
Pharmaceutical Research.
1325-1336.
2003
- Pressure-induced aggregation of interleukin-1 receptor antagonist (IL-1RA) - Mechanism and thermodynamics.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U175-U175. 2003
- High-pressure refolding of bikunin protein aggregates: efficacy and thermodynamics.. Biochemistry. 8643-8643. 2003
- Pressure-induced aggregation of interleukin-1 receptor antagonist (IL-1ra): mechanism and thermodynamics. Biochemistry. 8628-8629. 2003
-
Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteins.
Protein Science.
1252-1261.
2003
-
Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.
Protein Science.
903-913.
2003
-
Mechanism of microparticle formation in the compressed antisolvent precipitation and photopolymerization (CAPP) process.
Langmuir.
3926-3934.
2003
-
Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-γ.
Journal of Pharmaceutical Sciences.
715-729.
2003
-
Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation.
Journal of Biological Chemistry.
10842-10850.
2003
- Using EPR spectroscopy in conjunction with FT-NIR spectroscopy to study crosslinking photopolymerization kinetics.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U680-U680. 2003
-
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease α-synuclein fibrillogenesis.
Biochemistry.
829-837.
2003
-
Computer simulation of convective and diffusive transport of controlled-release drugs in the vitreous humor.
Pharmaceutical Research.
96-102.
2003
-
Effects of drying methods and additives on the structure, function, and storage stability of subtilisin: role of protein conformation and molecular mobility.
Enzyme and Microbial Technology.
765-774.
2002
-
Dissolution and partitioning behavior of hydrophobic ion-paired compounds.
Pharmaceutical Research.
1572-1576.
2002
- Protein aggregation at interfaces formed during lyophilization.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U226-U226. 2002
- Protein aggregation-conformational stability and colloidal stability.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U225-U225. 2002
- Protein refolding at high hydrostatic pressure.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U229-U229. 2002
-
Kinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein - Insights into transition states from pressure, temperature, and co-solute studies.
Journal of Biological Chemistry.
27240-27246.
2002
-
Hydrophobic ion pairing of isoniazid using a prodrug approach.
Journal of Pharmaceutical Sciences.
1502-1511.
2002
-
Surface adsorption of recombinant human interferon-γ in lyophilized and spray-lyophilized formulations.
Journal of Pharmaceutical Sciences.
1474-1487.
2002
-
Aggregation of granulocyte colony stimulating factor under physiological conditions: Characterization and thermodynamic inhibition.
Biochemistry.
6422-6431.
2002
-
Compressed antisolvent precipitation and photopolymerization to form highly cross-linked polymer particles.
Macromolecules.
4289-4296.
2002
-
High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.
Biochimica et Biophysica Acta - Proteins and Proteomics.
224-234.
2002
-
A new mechanism for decreasing aggregation of recombinant human interferon-γ by a surfactant:: Slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20.
Journal of Pharmaceutical Sciences.
543-558.
2002
-
High-pressure refolding of disulfide-cross-linked lysozyme aggregates: Thermodynamics and optimization.
Biotechnology Progress.
565-571.
2002
-
Surfactant-protein interactions..
Pharmaceutical biotechnology.
159-175.
2002
-
High pressure refolding of recombinant human growth hormone from insoluble aggregates - Structural transformations, kinetic barriers, and energetics.
Journal of Biological Chemistry.
46856-46863.
2001
-
Electrochemical determination of dissolution rates of lyophilized pharmaceutical formulations.
Analytical Chemistry.
5296-5301.
2001
-
The effects of tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution.
Journal of Pharmaceutical Sciences.
1466-1477.
2001
-
Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine Tg′ in pharmaceutical lyophilization.
Journal of Pharmaceutical Sciences.
872-887.
2001
-
The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf.
Journal of Pharmaceutical Sciences.
860-871.
2001
-
Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: High-pressure and cosolute studies on recombinant human IFN-γ.
Proceedings of the National Academy of Sciences of the United States of America.
7259-7264.
2001
-
Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying.
Archives of Biochemistry and Biophysics.
35-41.
2001
-
In vivo evaluation of antibiotic impregnated beads in a rat osteomyelitis model.
Journal of Bioactive and Compatible Polymers.
235-250.
2001
- Use of polymer/sugar mixtures to optimize storage stability of freeze-dried recombinant human interleukin-11.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U109-U109. 2001
-
In vivo evaluation of gentamicin impregnated polylactic acid beads implanted in sheep.
Journal of Bioactive and Compatible Polymers.
119-135.
2001
-
Counteracting effects of renal solutes on amyloid fibril formation by immunoglobulin light chains.
Journal of Biological Chemistry.
1626-1633.
2001
-
The excluding effects of sucrose on a protein chemical degradation pathway: Methionine oxidation in subtilisin.
Archives of Biochemistry and Biophysics.
123-132.
2000
-
Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor.
Journal of Pharmaceutical Sciences.
1480-1485.
2000
- Entrapping intermediates of thermal aggregation in α-helical proteins with low concentration of guanidine hydrochloride. Journal of Biological Chemistry. 27689-27693. 2000
-
Permeability and diffusion in vitreous humor: Implications for drug delivery.
Pharmaceutical Research.
664-669.
2000
-
Mechanism governing microparticle morphology during precipitation by a compressed antisolvent: Atomization vs nucleation and growth.
Journal of Physical Chemistry B.
2725-2735.
2000
-
Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran.
Journal of Pharmaceutical Sciences.
199-214.
2000
-
Thermodynamic modulation of light chain amyloid fibril formation.
Journal of Biological Chemistry.
1570-1574.
2000
-
Pressure dependence of subtilisin crystallization kinetics.
Journal of Crystal Growth.
678-686.
2000
-
Stability of subtilisin and lysozyme under high hydrostatic pressure.
Biotechnology Progress.
630-636.
2000
-
High pressure fosters protein refolding from aggregates at high concentrations.
Proceedings of the National Academy of Sciences of the United States of America.
13029-13033.
1999
-
Water-in-carbon dioxide emulsions: Formation and stability.
Langmuir.
6781-6791.
1999
-
Pressure effect on subtilisin crystallization and solubility.
Journal of Crystal Growth.
563-574.
1999
-
Investigation of protein-surfactant interactions by analytical ultracentrifugation and electron paramagnetic resonance: The use of recombinant human tissue factor as an example.
Pharmaceutical Research.
808-812.
1999
-
Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.
Archives of Biochemistry and Biophysics.
289-298.
1999
-
Protein formulation and lyophilization cycle design: Prevention of damage due to freeze-concentration induced phase separation.
Biotechnology and Bioengineering.
166-174.
1999
-
Role of crystallinity in retention of polymer particle morphology in the presence of compressed carbon dioxide.
Macromolecules.
1890-1896.
1999
-
Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization.
Archives of Biochemistry and Biophysics.
191-201.
1999
-
Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid.
Journal of Pharmaceutical Sciences.
281-290.
1999
-
Conformational stability of lyophilized PEGylated proteins in a phase-separating system.
Journal of Pharmaceutical Sciences.
58-64.
1999
- Inhibition of stress-induced aggregation of protein therapeutics. Methods in Enzymology. 236-255. 1999
- Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant, human factor XIII. Journal of Pharmaceutical Sciences. 1597-1603. 1998
-
Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid.
Archives of Biochemistry and Biophysics.
121-134.
1998
-
Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions.
Journal of Pharmaceutical Sciences.
1554-1559.
1998
-
A transient expansion of the native state precedes aggregation of recombinant human interferon-γ.
Proceedings of the National Academy of Sciences of the United States of America.
14142-14146.
1998
-
Effects of drying methods and additives on structure and function of actin: Mechanisms of dehydration-induced damage and its inhibition.
Archives of Biochemistry and Biophysics.
171-181.
1998
-
Aggregation of recombinant human interferon gamma: Kinetics and structural transitions.
Journal of Pharmaceutical Sciences.
1069-1076.
1998
-
Effects of tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin.
Journal of Pharmaceutical Sciences.
1062-1068.
1998
-
Preparation and in vitro characterization of gentamycin-impregnated biodegradable beads suitable for treatment of osteomyelitis.
Journal of Pharmaceutical Sciences.
1149-1154.
1998
-
Alveolar macrophage cell line is not activated by exposure to polymeric microspheres.
International Journal of Pharmaceutics.
41-49.
1998
-
Process variable implications for residual solvent removal and polymer morphology in the formation of gentamycin-loaded poly(L-lactide) microparticles.
Pharmaceutical Research.
1233-1237.
1998
- Rotational relaxation in supercritical carbon dioxide.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U187-U188. 1998
-
Rotational relaxation in supercritical carbon dioxide revisited: A study of solute-induced local density augmentation.
Journal of Physical Chemistry A.
1674-1681.
1998
-
Effect of salts and sugars on phase separation of polyvinylpyrrolidone-dextran solutions induced by freeze-concentration.
Journal of the Chemical Society, Faraday Transactions.
411-417.
1998
-
Phase separation of excipients during lyophilization: Effects on protein stability.
Journal of Pharmaceutical Sciences.
1198-1203.
1997
-
Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: Role in restricted conformational mobility and compaction of native state.
Proceedings of the National Academy of Sciences of the United States of America.
11917-11922.
1997
-
Manipulation of lyophilization-induced phase separation: Implications for pharmaceutical proteins.
Biotechnology Progress.
590-596.
1997
-
Water core within perfluoropolyether-based microemulsions formed in supercritical carbon dioxide.
Journal of Physical Chemistry B.
6707-6714.
1997
-
Rational design of stable lyophilized protein formulations: Some practical advice.
Pharmaceutical Research.
969-975.
1997
-
Ultrasonic velocity measurements in supercritical jet fuel.
Journal of Supercritical Fluids.
65-70.
1997
- Secondary structural protection of freeze-dried lysozyme is lost at high initial trehalose concentrations.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 76-IEC. 1997
- Characterization of truncated forms of human tissue factor-surfactant mixed micelles by analytical ultracentrifugation and EPR spectroscopy.. Biophysical Journal. MP311-MP311. 1997
-
Controlled release of ionic compounds from poly (L-lactide) microspheres produced by precipitation with a compressed antisolvent.
Journal of Controlled Release.
77-85.
1997
- A discussion of limitations on the use of polymers for stabilization of proteins during the freezing portion of lyophilization. ACS Symposium Series. 90-108. 1997
- Surfactant-stabilized protein formulations: A review of protein-surfactants interactions and novel analytical methodologies. ACS Symposium Series. 206-222. 1997
-
Effects of phase separating systems on lyophilized hemoglobin.
Journal of Pharmaceutical Sciences.
1358-1362.
1996
-
Molten globule intermediate of recombinant human growth hormone: Stabilization with surfactants.
Biotechnology Progress.
801-809.
1996
-
Effects of sugars and polymers on crystallization of poly(ethylene glycol) in frozen solutions: Phase separation between incompatible polymers.
Pharmaceutical Research.
1393-1400.
1996
- Toxicology of a PFPE surfactant. Science. 1726-1726. 1996
- Electron paramagnetic resonance spectroscopic measurement of surfactant:protein binding stoichiometries. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 216-BIOT. 1996
- The effects of polymer liquid-liquid phase separation on hemoglobin during freezing and drying.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 140-BIOT. 1996
- Theoretical examination of protein-polymer thermodynamic interactions during freezing.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 139-BIOT. 1996
-
Do solute-solute interactions affect activation limited reactions? A Brownian dynamics study.
Journal of Supercritical Fluids.
51-55.
1996
-
Molecular simulation and electron paramagnetic resonance (EPR) studies of rapid bimolecular reactions in supercritical fluids.
International Journal of Thermophysics.
471-481.
1996
-
Water in carbon dioxide microemulsions: An environment for hydrophiles including proteins.
Science.
624-626.
1996
-
Influence of local structural correlations on free-radical reactions in supercritical fluids: A hierarchical approach.
Industrial & Engineering Chemistry Research.
19-27.
1996
- MOLTEN GLOBULE INTERMEDIATE OF HUMAN GROWTH-HORMONE - CHARACTERIZATION AND INTERACTION WITH SURFACTANTS. The FASEB Journal. A1242-A1242. 1995
- THE EFFECTS OF TEMPERATURE AND SURFACTANT CONCENTRATION ON THE CONFORMATIONAL STABILITY OF RECOMBINANT HEMOGLOBIN. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 197-BIOT. 1995
-
EFFECT OF SOLUTE-SOLUTE CORRELATIONS ON RAPID REACTIONS IN SUPERCRITICAL FLUIDS.
AIChE Journal.
346-356.
1995
-
STABILITY OF PROTEIN FORMULATIONS - INVESTIGATION OF SURFACTANT EFFECTS BY A NOVEL EPR SPECTROSCOPIC TECHNIQUE.
Pharmaceutical Research.
2-11.
1995
-
DOES CRITICAL CLUSTERING AFFECT REACTION-RATE CONSTANTS - MOLECULAR-DYNAMICS STUDIES IN PURE SUPERCRITICAL FLUIDS.
The Journal of physical chemistry.
4173-4179.
1994
- MAPPING OF THE SURFACE OF RECOMBINANT HUMAN GROWTH-HORMONE TO STUDY PROTEIN-SURFACTANT INTERACTIONS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 81-BIOT. 1994
- SURFACTANT-PROTEIN INTERACTIONS AND THEIR ROLE IN PROTEIN STABILIZATION. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 80-BIOT. 1994
-
SUB-MICROMETER-SIZED BIODEGRADABLE PARTICLES OF POLY(L-LACTIC ACID) VIA THE GAS ANTISOLVENT SPRAY PRECIPITATION PROCESS.
Biotechnology Progress.
429-435.
1993
-
QUASICRITICAL BEHAVIOR OF DENSE-GAS SOLVENT-SOLUTE CLUSTERS AT NEAR-INFINITE DILUTION.
AIChE Journal.
1061-1071.
1993
-
DENSE-GAS SOLVENT-SOLUTE CLUSTERS AT NEAR-INFINITE DILUTION - EPR SPECTROSCOPIC EVIDENCE.
AIChE Journal.
876-884.
1993
- EPR SPECTROSCOPIC INVESTIGATIONS OF PROTEIN-SURFACTANT INTERACTIONS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 56-BIOT. 1993
-
FREE-RADICAL REACTIONS IN SUPERCRITICAL ETHANE - A PROBE OF SUPERCRITICAL FLUID STRUCTURE.
The Journal of physical chemistry.
5146-5151.
1992
- MECHANISM OF POLYETHYLENE-GLYCOL INTERACTION WITH THE MOLTEN GLOBULE FOLDING INTERMEDIATE OF BOVINE CARBONIC ANHYDRASE-B. Journal of Biological Chemistry. 3147-3153. 1992
-
CALORIMETRIC CONTROL OF FED-BATCH FERMENTATIONS.
Biotechnology and Bioengineering.
678-684.
1990
-
SUPERCRITICAL FLUID EXTRACTIONS IN BIOTECHNOLOGY.
Trends in Biotechnology.
78-82.
1990
-
ENZYME-CATALYZED OXIDATION OF CHOLESTEROL IN SUPERCRITICAL CARBON-DIOXIDE.
AIChE Journal.
1354-1360.
1988
-
CHOLESTEROL AGGREGATION AND INTERACTION WITH CHOLESTEROL OXIDASE IN SUPERCRITICAL CARBON-DIOXIDE.
Proceedings of the National Academy of Sciences of the United States of America.
2979-2983.
1988
-
ENZYMATIC OXIDATION OF CHOLESTEROL AGGREGATES IN SUPERCRITICAL CARBON-DIOXIDE.
Science.
387-390.
1988
- EFFECT OF ENZYME AND SUBSTRATE CONFORMATION ON ENZYMATIC-ACTIVITY IN A SUPERCRITICIAL FLUID - KINETIC AND ELECTRON-SPIN-RESONANCE STUDIES. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 24-MBTD. 1987
-
ENZYMATIC CATALYSIS IN A SUPERCRITICAL FLUID.
Biotechnology Letters.
325-328.
1985
-
Lipid-free, thermostable mRNA vaccines prepared using atomic layer deposition..
Journal of Pharmaceutical Sciences.
104066.
2026
Background
education and training
- Ph.D., University of California-Berkeley 1987
- B.S., University of Colorado Boulder 1983
awards and honors
International Activities
geographic focus
- Austria Country
- Europe Continent
- France Country
- Germany Country
- Japan Country
- Netherlands Country
- United Republic of Tanzania Country