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Parker, Roy Distinguished Professor, Cech-Leinwand Endowed Chair of Biochemistry, and Howard Hughes Medical Institute Investigator

Positions

Research Areas research areas

Research

research overview

  • My current major area of work is to understand the molecular mechanisms that control eukaryotic mRNAs in the cytoplasm with a specifc focus on the control of translation, mRNA localization and stability. We employ a variety of experimental models including bakers yeast, mammalian cells in culture, Drosophila and mice. Current work focuses on trying to understand how RNP granules, such as P-bodies and stress granules assemble, their roles in regulating mRNA function in cells, and how perturbations of these assemblies can cause human disease. This work also includes studies of related mRNP granules in neurons and regenerating muscle, both in normal conditions and during pathologies.

keywords

  • mRNA turnover, translation, P-bodies, mRNA degradation, Eukaryotic cells

Publications

selected publications

Teaching

courses taught

  • BCHM 4761 - Biochemistry Laboratory
    Primary Instructor - Spring 2018
    Two 4-hour periods per week. Introduction to modern biochemical techniques. Topics include enzymology, spectrophotometry, electrophoresis, multi-step protein purification, recombinant DNA techniques and molecular cloning. Formerly CHEM 4761.
  • CHEM 1041 - Biotechnology and Society
    Primary Instructor - Spring 2019
    Covers recent advances in biotechnology and how those impact society. Content and discussion will focus on both the science behind technological advances, their impact on society, and the ethical issues raised by new technologies. Topics change each semester but can include: GMO crops, genome editing, drug discovery and development, stem cell therapies, development and use of new cancer treatments, human genome sequencing and its impact on diagnosis and treatments, human microbiome, neurodegenerative diseases. Formerly CHEM 1041.
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
    May be repeated up to 15 total credit hours.

Background

awards and honors

International Activities

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