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Publications in VIVO

Parker, Roy

Distinguished Professor, Cech-Leinwand Endowed Chair of Biochemistry, and Howard Hughes Medical Institute Investigator

Positions

Research Areas research areas

Research

research overview

  • My current major area of work is to understand the molecular mechanisms that control eukaryotic mRNAs in the cytoplasm with a specific focus on the control of translation, mRNA localization and stability. We employ a variety of experimental models, primarily mammalian cells in culture. Current work focuses on trying to understand how RNP granules, such as P-bodies and stress granules assemble, their roles in regulating mRNA function in cells, and how perturbations of these assemblies can cause human disease. This work also includes studies of related mRNP granules in neurons and how pathological protein aggregates (such as tau) are actually RNP assemblies.

keywords

  • mRNA turnover, translation, mRNP granules, neurodegenerative disease

Publications

selected publications

Teaching

courses taught

  • BCHM 1041 - Biotechnology and Society
    Primary Instructor - Spring 2022
    Covers recent advances in biotechnology and how those impact society. Content and discussion will focus on both the science behind technological advances, their impact on society, and the ethical issues raised by new technologies. Topics change each semester but can include: GMO crops, genome editing, drug discovery and development, stem cell therapies, development and use of new cancer treatments, human genome sequencing and its impact on diagnosis and treatments, human microbiome, neurodegenerative diseases. Formerly CHEM 1041.
  • BCHM 6901 - Research in Biochemistry
    Primary Instructor - Fall 2019 / Spring 2020 / Fall 2020 / Spring 2021 / Fall 2021 / Fall 2022 / Spring 2023 / Fall 2024
    May be repeated up to 15 total credit hours.
  • CHEM 1041 - Biotechnology and Society
    Primary Instructor - Spring 2019
    Covers recent advances in biotechnology and how those impact society. Content and discussion will focus on both the science behind technological advances, their impact on society, and the ethical issues raised by new technologies. Topics change each semester but can include: GMO crops, genome editing, drug discovery and development, stem cell therapies, development and use of new cancer treatments, human genome sequencing and its impact on diagnosis and treatments, human microbiome, neurodegenerative diseases. Formerly CHEM 1041.
  • CHEM 4761 - Biochemistry Laboratory
    Primary Instructor - Spring 2018
    Two 4-hour periods per week. Introduction to modern biochemical techniques. Topics include enzymology, spectrophotometry, electrophoresis, multi-step protein purification, recombinant DNA techniques and molecular cloning. Formerly CHEM 4761.
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Fall 2018 / Spring 2019
    May be repeated up to 15 total credit hours.

Background

awards and honors

International Activities

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